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AB131702

Recombinant Human UBTD2 protein

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Recombinant Human UBTD2 protein is a Human Full Length protein, in the 1 to 234 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

DCUBP, SB72, UBTD2, Ubiquitin domain-containing protein 2, Dendritic cell-derived ubiquitin-like protein, Ubiquitin-like protein SB72, DC-UbP

1 Images
SDS-PAGE - Recombinant Human UBTD2 protein (AB131702)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UBTD2 protein (AB131702)

15% SDS-PAGE showing ab131702 at approximately 28.6 kDa (3µg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q8WUN7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYECQLRLRLSTGKDLKLVVRSTDTVFHMKRRLHAAEGVEPGSQRWFFSGRPLTDKMKFEELKIPKDYVVQVIVSQPVQNPTPVEN","proteinLength":"Full Length","predictedMolecularWeight":"28.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":234,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WUN7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBTD2 also known as Ubiquitin Domain Containing 2 is a protein that plays a role in cellular processes involving ubiquitination. It has a molecular mass of approximately 22 kDa. UBTD2 is widely expressed in human tissues with notable levels in the brain liver and heart. The protein contains a ubiquitin-like domain suggesting involvement in pathways related to protein degradation or signaling.
Biological function summary

UBTD2 regulates protein turnover by interacting with the ubiquitin-proteasome system impacting cellular stress responses. UBTD2 is part of a complex that includes other proteins such as E3 ubiquitin ligases which facilitate the tagging of proteins for degradation. This function impacts various pathways in response to cell damage or stress aiding in the maintenance of cellular health by removing misfolded or damaged proteins.

Pathways

The activity of UBTD2 fits into processes such as the cell cycle and apoptosis regulation. In the ubiquitin-proteasome pathway UBTD2 collaborates with proteins like HECTD3 an E3 ubiquitin ligase to mediate the degradation of specific proteins involved in these pathways. Its role in these processes highlights its importance in maintaining cellular homeostasis and ensuring proper cell cycle progression.

UBTD2 is linked with cancer and neurodegenerative diseases. Altered expression of UBTD2 has been observed in certain types of cancer suggesting it may influence tumor progression. Additionally its connection to neurodegenerative diseases points to its role in proteostasis failure often seen in disorders such as Alzheimer's disease. UBTD2 interacts with proteins like Tau which are known to accumulate abnormally in neurodegenerative conditions.

Specifications

Form

Liquid

Additional notes

ab131702 is purified using conventional chromatography techniques

General info

Product protocols

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