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AB79512

Recombinant Human UCP3 protein

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Recombinant Human UCP3 protein is a Human Fragment protein, in the 181 to 214 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

SLC25A9, UCP3, Putative mitochondrial transporter UCP3, Solute carrier family 25 member 9, Uncoupling protein-3, UCP 3

1 Images
SDS-PAGE - Recombinant Human UCP3 protein (AB79512)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UCP3 protein (AB79512)

20% SDS PAGE gel. Commassie blue staining.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

P55916

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in 1 mL of water

Storage buffer

Constituents: 2.68% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLT","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":214,"aminoAcidStart":181,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55916","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UCP3 also known as uncoupling protein 3 is a member of the mitochondrial transporter superfamily. It has a molecular mass of approximately 33 kDa. This protein is predominantly found in skeletal muscle and brown adipose tissue where it resides in the inner membrane of mitochondria. UCP3 functions by facilitating the proton leak across the mitochondrial membrane decoupling oxidative phosphorylation from ATP synthesis and therefore reducing the mitochondrial membrane potential.
Biological function summary

The function of UCP3 is involved in the regulation of energy metabolism. It modulates the production of heat by dissipating the proton gradient which otherwise drives ATP synthesis. This makes it an important actor in thermoregulation and metabolic efficiency. UCP3 forms part of a broader set of uncoupling proteins which include UCP1 and UCP2 each playing slightly different roles in energy metabolism and mitochondrial function.

Pathways

UCP3 influences the energy balance within cells by integrating into metabolic processes like fatty acid oxidation and thermogenesis. It plays a role in the mitochondrial oxidative phosphorylation pathway. UCP3's activity in these pathways also links it to other proteins such as UCP1 which is important in brown fat for thermogenesis and it interacts indirectly with enzymes involved in fatty acid metabolism.

Researchers associate UCP3 with metabolic conditions such as obesity and type 2 diabetes. Altered UCP3 expression can impact the efficiency of energy expenditure and thermoregulation potentially leading to these disorders. In the context of obesity and diabetes UCP3's interaction with other proteins like insulin-related signaling molecules highlights its indirect role in glucose homeostasis and lipid metabolism dysfunction.
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Specifications

Form

Lyophilized

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General info

Function

Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed : 21775425, PubMed : 36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed : 11171965, PubMed : 12670931, PubMed : 12734183, PubMed : 9305858). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed : 11707458).

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Subcellular localisation

Mitochondrion inner membrane

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Product protocols

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Target data

Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed : 21775425, PubMed : 36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed : 11171965, PubMed : 12670931, PubMed : 12734183, PubMed : 9305858). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed : 11707458).
See full target information UCP3
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