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AB96771

Recombinant Human UGDH protein

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Recombinant Human UGDH protein is a Human protein, in the 1 to 494 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH

1 Images
SDS-PAGE - Recombinant Human UGDH protein (AB96771)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UGDH protein (AB96771)

15% SDS-PAGE showing ab96771 at approximately 59.5kDa (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O60701

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.42% Sodium fluoride, 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSELEMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDPPNKKPKV","proteinLength":null,"predictedMolecularWeight":"59.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":494,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O60701","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UDP-glucose 6-dehydrogenase also known as UGDH is an enzyme with a mass of approximately 53 kDa. It catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid in humans. This enzyme plays an important mechanical role in the biosynthesis of glycosaminoglycans and is expressed in various tissues such as the liver kidneys and lungs. Alternate names for UGDH include UDP-GlcDH and UDPGDH frequently used in scientific literature.
Biological function summary

UDP-glucose 6-dehydrogenase contributes to the conversion processes for nucleotide sugar substrates and it is not reported to be part of a larger enzyme complex. It ensures the availability of UDP-glucuronic acid a necessary precursor for glycosaminoglycans which are components of the extracellular matrix and involved in cellular signaling. This activity supports processes like wound healing and tissue regeneration by maintaining structural integrity and facilitating cell-cell communication in various physiological contexts.

Pathways

UDP-glucose 6-dehydrogenase participates in the hexosamine biosynthetic pathway and the UDP-glucuronate pathway. In the hexosamine biosynthetic pathway it works alongside proteins like glutamine-fructose-6-phosphate transaminase to regulate the production of UDP-GlcNAc important for carbohydrate modifications of proteins and lipids. The UDP-glucuronate pathway involves related enzymes such as hyaluronan synthase which utilizes UDP-glucuronic acid generated by UGDH for synthesizing hyaluronan an important glycosaminoglycan in tissue hydration and lubrication.

Abnormal activity or expression of UDP-glucose 6-dehydrogenase links to cancer and fibrosis. Its role in producing glycosaminoglycans makes it significant in the tumor microenvironment and alterations in UGDH activity may support cancer progression by affecting cell adhesion and migration. In fibrosis overactivity of UGDH can lead to excessive glycosaminoglycan production contributing to tissue scarring. Interactions with proteins like hyaluronan synthase hint at potential therapeutic targets for modifying these extracellular matrix components in disease contexts.
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Specifications

Form

Liquid

Additional notes

ab96771 is purified using conventional chromatography techniques.

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General info

Function

Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed : 21502315, PubMed : 21961565, PubMed : 22123821, PubMed : 23106432, PubMed : 25478983, PubMed : 27966912, PubMed : 30420606, PubMed : 30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed : 32001716).

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

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Product protocols

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Target data

Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed : 21502315, PubMed : 21961565, PubMed : 22123821, PubMed : 23106432, PubMed : 25478983, PubMed : 27966912, PubMed : 30420606, PubMed : 30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed : 32001716).
See full target information UDP-glucose 6-dehydrogenase
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