Recombinant Human ULBP1 protein is a Human Full Length protein, in the 26 to 216 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M G W V D T H C L C Y D F I I T P K S R P E P Q W C E V Q G L V D E R P F L H Y D C V N H K A K A F A S L G K K V N V T K T W E E Q T E T L R D V V D F L K G Q L L D I Q V E N L I P I E P L T L Q A R M S C E H E A H G H G R G S W Q F L F N G Q K F L L F D S N N R K W T A L H P G A K K M T E K W E K N R D V T M F F Q K I S L G D C K M W L E E F L M Y W E Q M L D P T K P P S L A P G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Alternative names
N2DL1, RAET1I, ULBP1, UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1
Recommended products
Recombinant Human ULBP1 protein is a Human Full Length protein, in the 26 to 216 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9BZM6-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M G W V D T H C L C Y D F I I T P K S R P E P Q W C E V Q G L V D E R P F L H Y D C V N H K A K A F A S L G K K V N V T K T W E E Q T E T L R D V V D F L K G Q L L D I Q V E N L I P I E P L T L Q A R M S C E H E A H G H G R G S W Q F L F N G Q K F L L F D S N N R K W T A L H P G A K K M T E K W E K N R D V T M F F Q K I S L G D C K M W L E E F L M Y W E Q M L D P T K P P S L A P G
- Accession
- Q9BZM6
- Protein length
- Full Length
- Predicted molecular weight
- 25 kDa
- Amino acids
- 26 to 216
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab134517 is purified by using conventional chromatography techniques.
General info
- Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
- Sequence similarities
Belongs to the MHC class I family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ULBP1 also known as UL16-binding protein 1 is a member of the MHC class I-related molecules. It weighs approximately 28 kDa. ULBP1 acts mechanically as a ligand for the NKG2D receptor part of the activating receptor on natural killer (NK) cells and certain T cells. It is primarily expressed on the surface of various cells including epithelial and some tumor cells. Its expression can be induced by cellular stress or infection.
- Biological function summary
This protein plays a critical role in immune surveillance and response to malignancies and infections. ULBP1 does not form a complex on its own but it works closely with other NKG2D ligands contributing to the immune system's ability to recognize and eliminate abnormal cells. Its presence can enhance immune cell-mediated cytotoxicity indicating its role in immune defense.
- Pathways
The protein takes an active part in the immune system activation interacting notably within the NK cell-mediated cytotoxicity pathway. It functions alongside other NKG2D ligands like MICA/MICB to modulate the activity of NK cells and T cells. This connection to the NKG2D pathway ensures a critical interface between innate and adaptive immunity reinforcing defense against infected or tumor cells.
- Associated diseases and disorders
Researchers have noted associations between ULBP1 and cancer progression or immune evasion. Its upregulation on tumor cells can lead to tumor clearance; however some cancers may shed ULBP1 to escape immune detection. In autoimmune diseases such as rheumatoid arthritis altered expression of ULBP1 and its interaction with NKG2D can potentially exacerbate inflammation. These interactions emphasize the balance that ULBP1 maintains in managing immune responses and its implications in pathology.
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1 product image
SDS-PAGE - Recombinant Human ULBP1 protein (ab134517)
15% SDS-PAGE analysis of ab134517 (3ug)
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