Recombinant Human Unc5a protein (His tag)
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Recombinant Human Unc5a protein (His tag) is a Human Fragment protein, in the 1 to 306 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
KIAA1976, UNC5H1, UNC5A, Netrin receptor UNC5A, Protein unc-5 homolog 1, Protein unc-5 homolog A
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Unc5a protein (His tag) (AB276540)
SDS-PAGE analysis of ab276540
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Unc5a influences processes beyond neural guidance. It is involved in cell adhesion migration and survival operating not only as a monomer but also as part of receptor complexes. Besides its role in neural tissue Unc5a also appears in various non-neural tissues. During development it contributes to the formation of tissue structure particularly in organisms' nervous systems. This multi-functionality highlights its importance in maintaining cellular integrity.
Pathways
Unc5a participates in the netrin signaling pathways which are important for neuronal navigation. The pathways involve interactions with key proteins like Dcc and members of the Rho family such as RhoA which help to mediate cytoskeletal dynamics. Unc5a engages in apoptotic pathways often acting on mitochondrial mechanisms to influence cell survival outcomes linking its regulatory functions with other apoptosis-related players like caspases.
Specifications
Form
Lyophilized
General info
Function
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Sequence similarities
Belongs to the unc-5 family.
Post-translational modifications
Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.. The two extracellular TSRs of UNC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans. DPY19L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third. C-mannosylation by DPY19L1 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface.
Target data
Product promise
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