Recombinant Human UNC5B protein (His tag)
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Recombinant Human UNC5B protein (His tag) is a Human Fragment protein, in the 1 to 363 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
P53RDL1, UNC5H2, UNQ1883/PRO4326, UNC5B, Netrin receptor UNC5B, Protein unc-5 homolog 2, Protein unc-5 homolog B, p53-regulated receptor for death and life protein 1, p53RDL1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human UNC5B protein (His tag) (AB276563)
SDS-PAGE analysis of ab276563
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Scientists understand UNC5B to mediate the anti-angiogenic effects within tissues. It is an essential component of the signaling pathways that govern apoptosis in response to cellular conditions. UNC5B forms part of a larger receptor complex with Netrin-1 which influences cellular directionality and guidance by affecting cytoskeletal dynamics.
Pathways
The UNC5B receptor prominently participates in the Netrin signaling pathway. Within this pathway UNC5B interacts with other proteins such as DCC (deleted in colorectal cancer) that are involved in axonal guidance and neuronal navigation. It also plays a part in the apoptotic signaling pathways which are important for regulating cell survival and programmed cell death.
Specifications
Form
Lyophilized
General info
Function
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed : 12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
Sequence similarities
Belongs to the unc-5 family.
Post-translational modifications
Phosphorylated on cytoplasmic tyrosine residues.. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.. Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
Target data
Complementary Products
![Western blot - Anti-UNC5B antibody [EPR18439] (AB189914)](https://content.abcam.com/products/images/unc5b-antibody-epr18439-ab189914--western-blot-img15818.jpg)
Product promise
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