Recombinant Human UPAR Protein (Active) is a Human Fragment protein, in the 23 to 303 aa range, expressed in HEK 293, with >=95% purity and <= 0.005 EU/µg endotoxin level.
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Key facts
- Purity
- >=95% HPLC
- Endotoxin level
- <= 0.005 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Biologically active
- Yes
Amino acid sequence
L R C M Q C K T N G D C R V E E C A L G Q D L C R T T I V R L W E E G E E L E L V E K S C T H S E K T N R T L S Y R T G L K I T S L T E V V C G L D L C N Q G N S G R A V T Y S R S R Y L E C I S C G S S D M S C E R G R H Q S L Q C R S P E E Q C L D V V T H W I Q E G E E G R P K D D R H L R G C G Y L P G C P G S N G F H N N D T F H F L K C C N T T K C N E G P I L E L E N L P Q N G R Q C Y S C K G N S T H G C S S E E T F L I D C R G P M N Q C L V A T G T H E P K N Q S Y M V R G C A T A S M C Q H A H L G D A F S M N H I D V S C C T K S G C N H P D L D V Q Y R
Target data
Function
Acts as a receptor for urokinase plasminogen activator (PubMed:15677461). Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Alternative names
CD87, MO3, UPAR, PLAUR, Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3
Recommended products
Recombinant Human UPAR Protein (Active) is a Human Fragment protein, in the 23 to 303 aa range, expressed in HEK 293, with >=95% purity and <= 0.005 EU/µg endotoxin level.
Key facts
- Purity
- >=95% HPLC
- Endotoxin level
- <= 0.005 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Biologically active
- Yes
- Biological activity
- Loaded Human UPA/Urokinase, His Tag on Ni2+ Biosensor can bind Human UPAR with an affinity constant of 0.82 nM as determined in BLI assay (GatorBio Prime).
- Accession
- Q03405-1
- Animal free
- No
- Species
- Human
- Reconstitution
- Reconstitute in PBS
- Concentration
- Storage buffer
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Sequence info
Amino acid sequence
- L R C M Q C K T N G D C R V E E C A L G Q D L C R T T I V R L W E E G E E L E L V E K S C T H S E K T N R T L S Y R T G L K I T S L T E V V C G L D L C N Q G N S G R A V T Y S R S R Y L E C I S C G S S D M S C E R G R H Q S L Q C R S P E E Q C L D V V T H W I Q E G E E G R P K D D R H L R G C G Y L P G C P G S N G F H N N D T F H F L K C C N T T K C N E G P I L E L E N L P Q N G R Q C Y S C K G N S T H G C S S E E T F L I D C R G P M N Q C L V A T G T H E P K N Q S Y M V R G C A T A S M C Q H A H L G D A F S M N H I D V S C C T K S G C N H P D L D V Q Y R
- Accession
- Q03405
- Protein length
- Fragment
- Amino acids
- 23 to 303
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Acts as a receptor for urokinase plasminogen activator (PubMed:15677461). Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Product promise
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Full details and terms and conditions can be found here:
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4 product images
Mass Spectrometry - Recombinant Human UPAR Protein (Active) (ab290079)
Mass determination by ESI-TOF.
Predicted MW is 31373.15 Da. (+/- 10 Da by ESI-TOF). Observed MW is 31220.92 Da.
M -156 Da, due to Arginine truncation
Biological Activity - Recombinant Human UPAR Protein (Active) (ab290079)
Loaded Human UPA/Urokinase, His Tag on Ni2+ Biosensor can bind Human UPAR with an affinity constant of 0.82 nM as determined in BLI assay (GatorBio Prime).
SDS-PAGE - Recombinant Human UPAR Protein (Active) (ab290079)
SDS-PAGE analysis of ab290079
HPLC - Recombinant Human UPAR Protein (Active) (ab290079)
HPLC analysis of ab290079
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