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AB151375

Recombinant Human UPB1 protein

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Recombinant Human UPB1 protein is a Human Full Length protein, in the 1 to 384 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

BUP1, UPB1, Beta-ureidopropionase, BUP-1, Beta-alanine synthase, N-carbamoyl-beta-alanine amidohydrolase

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UBR1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"43.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":384,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9UBR1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UPB1 also known as Ureidopropionase beta is an enzyme encoded by the UPB1 gene. It is approximately 37 kDa in mass. UPB1 conducts the hydrolysis of N-carbamoyl-beta-alanine and N-carbamoyl-beta-aminoisobutyric acid to provide beta-alanine beta-aminoisobutyric acid ammonia and carbon dioxide. It is commonly expressed in liver and kidney tissues.
Biological function summary

UPB1 plays an important role in the catabolic pathway of pyrimidine metabolism. This enzyme participates in the breakdown of uracil which is part of nucleotide catabolism. UPB1 operates independently rather than as a part of a protein complex. It ensures detoxification and recycling of nitrogenous compounds derived from pyrimidine breakdown.

Pathways

UPB1 is an integral component of the pyrimidine metabolic pathway. It provides a link between the pyrimidine degradation pathway and general nitrogen metabolism by supplying beta-alanine. This function complements the enzymatic roles of dihydropyrimidine dehydrogenase (DPYD) and dihydropyrimidinase (DPYS) which are involved in earlier steps in the same degradation pathway.

Disturbances associated with UPB1 can lead to a condition called N-carbamoyl-beta-amino aciduria. This is a metabolic disorder characterized by excessive accumulation of N-carbamoyl-beta-amino acids in urine. The interaction with proteins such as DPYS and DPYD may exacerbate or modify the severity of this metabolic condition as they are upstream components in the pyrimidine degradation pathway.
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Specifications

Form

Liquid

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General info

Function

Catalyzes a late step in pyrimidine degradation (PubMed : 22525402, PubMed : 24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed : 10415095, PubMed : 10542323, PubMed : 11508704, PubMed : 22525402, PubMed : 24526388, PubMed : 29976570). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable).

Sequence similarities

Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.

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Product protocols

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Target data

Catalyzes a late step in pyrimidine degradation (PubMed : 22525402, PubMed : 24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed : 10415095, PubMed : 10542323, PubMed : 11508704, PubMed : 22525402, PubMed : 24526388, PubMed : 29976570). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable).
See full target information UPB1
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Complementary Products

Primary Antibodies

AB249303

Anti-UPB1 antibody [EPR9132] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-UPB1 antibody [EPR9132] - BSA and Azide free (AB249303)

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