Recombinant Human UPRT protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

UPRT functions within the pyrimidine salvage pathway aiding in the maintenance of nucleotide pools by recycling uracil. This role is significant as it impacts various cellular functions especially under conditions of nutrient scarcity. UPRT does not form part of a large complex rather it acts independently to execute its enzymatic activity. Its activity ensures uracil recycle into UMP which then enters nucleotide and RNA synthesis pathways contributing to cellular growth and replication.

Pathways

UPRT activity is important in the pyrimidine salvage pathway and contributes to maintaining the balance of pyrimidine nucleotides within the cell. It works in conjunction with other enzymes like uridine kinase and thymidylate kinase which contribute to nucleotide biosynthesis and nucleic acid metabolism. The balance of these pathways supports DNA replication RNA transcription and cell division linking UPRT tightly with cellular proliferation and function.