Recombinant Human Uridine Phosphorylase 1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Uridine Phosphorylase 1 plays an important role in the salvage pathway that maintains nucleotide homeostasis. This process is essential for the efficient recycling of nucleotides which supports DNA and RNA synthesis especially under conditions of limited de novo synthesis. UPP1 does not function as part of a larger enzyme complex operating independently for its specific biochemical activity. The enzyme helps maintain an adequate supply of uracil and cytosine which are important for many cellular processes including cell growth and division.

Pathways

Uridine Phosphorylase 1 is significantly involved in the pyrimidine salvage pathway and is also interconnected with the broader nucleotide metabolism pathway. These pathways are essential for the recycling and synthesis of nucleotides required for nucleic acid production. UPP1 works closely with thymidine phosphorylase (TYMP) and uridine-cytidine kinase both of which are vital in maintaining cellular nucleotide balance. These interactions between enzymes help ensure that cells have the necessary components for vital functions like DNA replication and repair.