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AB156344

Recombinant Human Use1 protein

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Recombinant Human Use1 protein is a Human Full Length protein, in the 1 to 231 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

USE1L, MDS032, USE1, Vesicle transport protein USE1, Putative MAPK-activating protein PM26, USE1-like protein, p31

1 Images
SDS-PAGE - Recombinant Human Use1 protein (AB156344)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Use1 protein (AB156344)

15% SDS-PAGE analysis of 3µg ab156344.

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NZ43

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAASRLELNLVRLLSRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKVHASKPASEVINEYSWKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSAEPEMDVRKRTGVAGSQPVSEKQSAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTESERLEQHTQKSVN","proteinLength":"Full Length","predictedMolecularWeight":"28.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":231,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NZ43","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Use1 also known as UNS-1 or Protein Transport Protein Use1 is involved in the SNARE-mediated transport mechanism. It has a molecular mass of approximately 29 kDa. This protein is expressed in various tissues with significant presence in the endoplasmic reticulum and Golgi apparatus. Structurally Use1 interacts with other SNARE proteins to regulate vesicle fusion processes essential for intracellular transport.
Biological function summary

Use1 plays an important role in the delivery and sorting of proteins within cells. It functions as a part of the SNARE complex which is important for the fusion of vesicles with target membranes. By ensuring the precise docking and release of vesicles this protein aids in maintaining proper cellular function. The SNARE complex including partners like Syntaxin 18 and BNIP1 ensures coordinated intracellular trafficking which is vital for cellular homeostasis.

Pathways

Use1 is deeply involved in the vesicular transport and cellular trafficking pathways. These pathways are essential for the movement of proteins and lipids between different organelles. Use1 works closely with the Golgi and endoplasmic reticulum trafficking pathways. It interacts with proteins such as Sec22b and Syntaxin 18 to facilitate vesicular transport processes. This activity ensures correct delivery of molecular cargos aiding in cellular function regulation and signal transduction.

Mutations or dysfunction of Use1 have been associated with neurodegenerative diseases and certain metabolic disorders. Neurodegenerative conditions like Alzheimer's disease show disrupted protein transport implicating Use1's role in proper neuronal function. Additionally Use1 connects with proteins like Syntaxin 5 highlighting its involvement in metabolic pathways that when altered may lead to disorders. Research continues to investigate Use1 as a potential therapeutic target for these conditions.
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Specifications

Form

Liquid

Additional notes

ab156344 was purified using conventional chromatography techniques.

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General info

Function

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Sequence similarities

Belongs to the USE1 family.

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Product protocols

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Target data

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
See full target information USE1
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Complementary Products

Primary Antibodies

AB234867

Anti-Use1 antibody

Western blot - Anti-Use1 antibody (AB234867)

  • 0
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Primary Antibodies

AB244205

Anti-15 Lipoxygenase 1 antibody [EPR22138]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunocytochemistry - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

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Primary Antibodies

AB254700

Anti-UBE2Z antibody

Western blot - Anti-UBE2Z antibody (AB254700)

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Proteins & Peptides

AB276251

Recombinant Human ICAM3 protein (Fc Chimera His Tag)

SDS-PAGE - Recombinant Human ICAM3 protein (Fc Chimera His Tag) (AB276251)

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