Recombinant Human USP31 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USP31 also known as Ubiquitin Specific Peptidase 31 belongs to the family of deubiquitinating enzymes. It plays a role in regulating protein homeostasis by removing ubiquitin from target proteins. USP31 has a molecular mass of approximately 140 kDa. It is expressed across various tissues but shows higher levels in the liver brain and immune cells. This expression pattern suggests its involvement in important cellular processes within these tissues.

Biological function summary

USP31 contributes to the regulation of NF-kB signaling pathways an important process in inflammation and immune responses. It acts by deubiquitinating and stabilizing specific substrates affecting the nuclear translocation of NF-kB. USP31 does not solely act but works as part of a larger complex within the cell interacting with other proteins to ensure precise regulation of signaling events. This action impacts the cell’s response to stress and pro-inflammatory signals.

Pathways

USP31 actively participates in the NF-kB pathway and the response to viral infections. In the context of the NF-kB pathway it closely interacts with proteins such as IKKα and IKKβ which are pivotal in NF-kB activation and can influence inflammatory outcomes. In relation to the antiviral response USP31 modulates pathways involving type I interferon production linking it with proteins like IRF3 and IRF7 critical for mounting an effective immune response against viral threats.

Dysfunction or altered expression of USP31 associates with conditions like chronic inflammation and certain cancers. In inflammatory diseases USP31’s erroneous activity amplifies or diminishes NF-kB signaling connecting it with inflammatory cytokines and proteins like TNF-α and IL-6. In cancer abnormalities in USP31 regulation contribute to unchecked cell growth and survival signals potentially working in tandem with proteins such as p53 and MDM2 which are central to the cellular stress response and tumor suppression mechanisms.