Recombinant Human USP46 protein
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Recombinant Human USP46 protein is a Human Full Length protein, in the 1 to 366 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human USP46 protein (AB177681)
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
USP46 modulates the ubiquitin-proteasome system by removing ubiquitin from substrate proteins which impacts their degradation or activity. It exists as part of a larger protein complex interacting with proteins such as WDR20 which enhance its activity. This interaction allows USP46 to regulate protein homeostasis within neurons and other cells. In the nervous system its activity supports synaptic function and plasticity contributing to effective neural communication and cognitive processes.
Pathways
USP46 mainly acts within the ubiquitin-proteasome pathway an essential mechanism for protein degradation and regulation. It interacts with proteins like UBE3A and UCH-L1 which are important for maintaining protein balance and cellular stress responses. Another important pathway involving USP46 is the neural plasticity and signaling pathway where it helps in regulating the degradation of synaptic proteins contributing to learning and memory.
Specifications
Form
Liquid
Additional notes
ab177681 is purified using conventional chromatography techniques.
General info
Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed : 19075014, PubMed : 26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed : 19075014).
Sequence similarities
Belongs to the peptidase C19 family. USP12/USP46 subfamily.
Target data
Complementary Products
Product promise
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