Recombinant Human UTP14A protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UTP14A also known as Utp14 or Sanpodo protein is a component of the ribosome biogenesis pathway. Mechanically UTP14A functions within the nucleolus where it plays a role in the early steps of 18S ribosomal RNA processing. UTP14A weighs approximately 103 kDa. Expression of UTP14A occurs in several tissues with higher expression observed in testis and various cancerous tissues. It primarily localizes in the nucleolus indicating its significant role in ribosomal biogenesis and protein synthesis.

Biological function summary

UTP14A aids in the assembly of preribosome complexes. It forms part of a larger complex known as the small ribosomal subunit processome where it contributes to the maturation of the 40S ribosomal subunit. As a member of the ribosome biogenesis pathway UTP14A has interactions with other nucleolar proteins including UTPA and UTPB complexes. These interactions are essential for effective ribosome production and subsequently overall cell growth and proliferation.

Pathways

UTP14A is essential in the nucleolar processing and ribosome assembly pathway. It connects with the ribosomal RNA processing pathway alongside related proteins like UTP11 and UTP21 which guide the maturation of ribosomal RNA and assembly of ribosomes. This essential activity links UTP14A to protein translation and cellular response to growth signals. The efficient operation of these pathways ensures proper cell cycle progression and division critical for maintaining normal cellular functions.

Alterations in UTP14A expression or function link to cancer and infertility. Specifically in certain cancers such as prostate and testicular cancer UTP14A exhibits upregulated expression suggesting a role in abnormal cell proliferation. Additionally mutations in UTP14A feature involvement in male infertility due to defective spermatogenesis since the protein interacts with USP9X a regulator of germ cell development. Understanding UTP14A's role in these disorders can lead to targeted therapeutic strategies.