Recombinant Human UTP23 protein is a Human Full Length protein, in the 1 to 249 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M K I T R Q K H A K K H L G F F R N N F G V R E P Y Q I L L D G T F C Q A A L R G R I Q L R E Q L P R Y L M G E T Q L C T T R C V L K E L E T L G K D L Y G A K L I A Q K C Q V R N C P H F K N A V S G S E C L L S M V E E G N P H H Y F V A T Q D Q N L S V K V K K K P G V P L M F I I Q N T M V L D K P S P K T I A F V K A V E S G Q L V S V H E K E S I K H L K E E Q G L V K N T E Q S R R K K R K K I S G P N P L S C L K K K K K A P D T Q S S A S E K K R K R K R I R N R S N P K V L S E K Q N A E G E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Involved in rRNA-processing and ribosome biogenesis.
Alternative names
C8orf53, UTP23, rRNA-processing protein UTP23 homolog
Recommended products
Recombinant Human UTP23 protein is a Human Full Length protein, in the 1 to 249 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9BRU9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M K I T R Q K H A K K H L G F F R N N F G V R E P Y Q I L L D G T F C Q A A L R G R I Q L R E Q L P R Y L M G E T Q L C T T R C V L K E L E T L G K D L Y G A K L I A Q K C Q V R N C P H F K N A V S G S E C L L S M V E E G N P H H Y F V A T Q D Q N L S V K V K K K P G V P L M F I I Q N T M V L D K P S P K T I A F V K A V E S G Q L V S V H E K E S I K H L K E E Q G L V K N T E Q S R R K K R K K I S G P N P L S C L K K K K K A P D T Q S S A S E K K R K R K R I R N R S N P K V L S E K Q N A E G E
- Accession
- Q9BRU9
- Protein length
- Full Length
- Predicted molecular weight
- 30.8 kDa
- Amino acids
- 1 to 249
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab134613 is purified using conventional chromatography techniques.
General info
- Function
Involved in rRNA-processing and ribosome biogenesis.
- Sequence similarities
Belongs to the UTP23/FCF1 family. UTP23 subfamily.
- Subcellular localisation
- Nucleus, Nucleolus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UTP23 also known as suppressor of los1 homolog 1 (SUSH1) is a protein involved in ribosome biogenesis specifically in the processing of small nucleolar ribonucleoproteins. The protein has a molecular mass of approximately 26 kDa. UTP23 is expressed mainly in the nucleolus of cells where ribosome assembly occurs. Its function involves participation in the cleavage of pre-rRNA necessary for the maturation of 18S rRNA which is an essential component of the small ribosomal subunit.
- Biological function summary
UTP23 participates in the formation of the small subunit (SSU) processome a large ribonucleoprotein complex essential for early stages of pre-rRNA processing. This complex plays an important role in the biogenesis of the 40S ribosomal subunit. The function of UTP23 in this complex ensures proper ribosome assembly impacting protein synthesis rates within the cell. The presence of UTP23 in the SSU processome highlights its importance in maintaining ribosome function integrity.
- Pathways
UTP23 is integral within the ribosome biogenesis pathway linking it to the synthesis and assembly of ribosomes. It interacts with proteins such as UTP4 and UTP18 which also contribute to pre-rRNA processing and ribosomal assembly. The correct functioning of these pathways is important for the production of functional ribosomes which impacts overall gene expression and cellular productivity.
- Associated diseases and disorders
Defects in UTP23 activity have associations with disorders such as Diamond-Blackfan anemia and Treacher Collins syndrome. Both conditions often involve disruptions in ribosomal biogenesis. UTP23's connection to proteins like ribosomal protein S19 (RPS19) in these disorders highlights its significance. These disorders highlight the importance of accurate function and regulation of UTP23 for maintaining normal cellular activity and preventing disease states.
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SDS-PAGE - Recombinant Human UTP23 protein (ab134613)
15% SDS-PAGE analysis of 3 µg ab134613.
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