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AB134613

Recombinant Human UTP23 protein

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Recombinant Human UTP23 protein is a Human Full Length protein, in the 1 to 249 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C8orf53, UTP23, rRNA-processing protein UTP23 homolog

1 Images
SDS-PAGE - Recombinant Human UTP23 protein (AB134613)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UTP23 protein (AB134613)

15% SDS-PAGE analysis of 3 µg ab134613.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9BRU9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMKITRQKHAKKHLGFFRNNFGVREPYQILLDGTFCQAALRGRIQLREQLPRYLMGETQLCTTRCVLKELETLGKDLYGAKLIAQKCQVRNCPHFKNAVSGSECLLSMVEEGNPHHYFVATQDQNLSVKVKKKPGVPLMFIIQNTMVLDKPSPKTIAFVKAVESGQLVSVHEKESIKHLKEEQGLVKNTEQSRRKKRKKISGPNPLSCLKKKKKAPDTQSSASEKKRKRKRIRNRSNPKVLSEKQNAEGE","proteinLength":"Full Length","predictedMolecularWeight":"30.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":249,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BRU9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UTP23 also known as suppressor of los1 homolog 1 (SUSH1) is a protein involved in ribosome biogenesis specifically in the processing of small nucleolar ribonucleoproteins. The protein has a molecular mass of approximately 26 kDa. UTP23 is expressed mainly in the nucleolus of cells where ribosome assembly occurs. Its function involves participation in the cleavage of pre-rRNA necessary for the maturation of 18S rRNA which is an essential component of the small ribosomal subunit.
Biological function summary

UTP23 participates in the formation of the small subunit (SSU) processome a large ribonucleoprotein complex essential for early stages of pre-rRNA processing. This complex plays an important role in the biogenesis of the 40S ribosomal subunit. The function of UTP23 in this complex ensures proper ribosome assembly impacting protein synthesis rates within the cell. The presence of UTP23 in the SSU processome highlights its importance in maintaining ribosome function integrity.

Pathways

UTP23 is integral within the ribosome biogenesis pathway linking it to the synthesis and assembly of ribosomes. It interacts with proteins such as UTP4 and UTP18 which also contribute to pre-rRNA processing and ribosomal assembly. The correct functioning of these pathways is important for the production of functional ribosomes which impacts overall gene expression and cellular productivity.

Defects in UTP23 activity have associations with disorders such as Diamond-Blackfan anemia and Treacher Collins syndrome. Both conditions often involve disruptions in ribosomal biogenesis. UTP23's connection to proteins like ribosomal protein S19 (RPS19) in these disorders highlights its significance. These disorders highlight the importance of accurate function and regulation of UTP23 for maintaining normal cellular activity and preventing disease states.
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Specifications

Form

Liquid

Additional notes

ab134613 is purified using conventional chromatography techniques.

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General info

Function

Involved in rRNA-processing and ribosome biogenesis.

Sequence similarities

Belongs to the UTP23/FCF1 family. UTP23 subfamily.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Involved in rRNA-processing and ribosome biogenesis.
See full target information UTP23
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Complementary Products

Primary Antibodies

AB235327

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UTP23 antibody (AB235327)

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Primary Antibodies

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Anti-CD16 antibody

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Primary Antibodies

AB183322

Anti-CD14 antibody [SP192]

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Primary Antibodies

AB134073

Anti-CD64 antibody [EPR4624]

RabMAb|Recombinant|KO Validated

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