Recombinant Human VCX-A protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VCX-A also known as Variably Charged X-linked protein A is part of a family of proteins that share a similar motif. It weighs approximately 15 kDa. VCX-A is mostly expressed in the testis specifically in germ cells suggesting a role in male reproduction. It is found in specific tissues with minimal expression in other organs which indicates its specialized function.

Biological function summary

The protein belongs to a group known for its involvement in cell cycle regulation indicating it may influence spermatogenesis. While detailed interactions of VCX-A remain under study its relation to the Variably Charged X-linked (VCX) protein family suggests it may form complexes to act as a modulator within cells. This regulation may involve phosphorylation states impacting how germ cells progress through developmental phases.

Pathways

The Variably Charged X-linked protein family takes part in cellular mechanisms ensuring proper cell division. In particular VCX-A might be associated with the regulation of the spermatogenic process and cell cycle checkpoints. It could interact with proteins linked to the regulation pathway of cyclins and cyclin-dependent kinases which play an essential role in cell cycle progression hinting at a connection with proteins like CDC25A.

VCX-A expression or dysfunction could potentially link to infertility due to abnormal germ cell development. Aberrations in proteins similar to VCX-A might also imply a connection with testicular dysgenesis syndrome. The protein's interaction with other members of its family or related regulatory proteins such as those involved in chromatin organization suggests a pathway potentially sensitive to malfunction contributing to these conditions.