Recombinant Human VEGFC protein (Active)
- Premium Bioactive
- What is this?
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human VEGFC protein (Active) is a Human Full Length protein, in the 112 to 227 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, FuncS.
View Alternative Names
Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Vascular endothelial growth factor-related protein, Flt4-L, VRP, VEGFC
- Biochemical assay
Supplier Data
Biochemical assay - Recombinant Human VEGFC protein (Active) (AB283476)
Fully biologically active determined by dose dependent induction of NFAT-mediated gene activation in HEK293 overexpressing human VEGFR2/KDR and NFAT-luciferase reporter cell line. ED50 is ≤ 10.4 ng/ml, corresponding to a specific activity of 9.6 x 104 units/mg.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human VEGFC protein (Active) (AB283476)
SDS-PAGE analysis of ab283476.
- HPLC
Supplier Data
HPLC - Recombinant Human VEGFC protein (Active) (AB283476)
HPLC analysis of ab283476.
Complementary Products
Reagents, Controls & Accessories
AB116029
Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)
- 5
- 1
Primary Antibodies
AB303710
Anti-VEGFC antibody [EPR22854-144] - BSA and Azide free (Capture)
RabMAb|Recombinant
![Sandwich ELISA - Anti-VEGFC antibody [EPR22854-144] - BSA and Azide free (Capture) (AB303710)](https://content.abcam.com/products/images/vegfc-antibody-epr22854-144-bsa-and-azide-free-capture-ab303710--sandwich-elisa-img403611.jpg)
- 0
- 0
Reactivity data
Sequence info
Properties and storage information
Form
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
VEGFC contributes to the regulation of vascular and lymphatic endothelial cell functions. It is not known to be part of a larger protein complex but exerts its functions through interactions with receptors such as VEGFR-3. By promoting cell proliferation and migration VEGFC assists in the repair and regeneration of tissues. Its role in fluid balance is essential as it helps maintain tissue equilibrium and immune function.
Pathways
VEGFC is integral to the VEGF signaling and lymphatic vessel development pathways. Within these processes VEGFC works alongside other proteins such as VEGFA and VEGFB to modulate vascular permeability and vessel formation. The interaction between VEGFC and the VEGFR-3 receptor specifically mediates lymphatic endothelial cell activation and function linking it to vital physiological processes like inflammation and tissue repair.
General info
Function
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Sequence similarities
Belongs to the PDGF/VEGF growth factor family.
Post-translational modifications
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com