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AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

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(1 Publication)

Recombinant human Vitronectin/S-Protein (Animal Free) is a Human Full Length protein, in the 20 to 478 aa range, expressed in HEK 293 cells, with >95%, suitable for SDS-PAGE, FuncS, HPLC.

View Alternative Names

Vitronectin, VN, S-protein, Serum-spreading factor, V75, VTN

Key facts

Purity

>95% SDS-PAGE

Expression system

HEK 293 cells

Tags

Tag free

Applications

HPLC, FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Recombinant human Vitronectin promotes attachment of hESC and iPSC in serum-free, feeder conditionsat 5ug/ml.

Accession

P04004

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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AB234577

Human Vitronectin/S-Protein ELISA Kit

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Sequence info

[{"sequence":"DQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLTSDLQAQSKGNPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQFISRDWHGVPGQVDAAMAGRIYISGMAPRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQNSRRPSRATWLSLFSSEESNLGANNYDDYRMDWLVPATCEPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAPGHL","proteinLength":"Full Length","predictedMolecularWeight":"52.29 kDa","actualMolecularWeight":null,"aminoAcidEnd":478,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P04004","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Lyophilized

Additional notes

>95% by HPLC.

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General info

Function

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Post-translational modifications

Sulfated on tyrosine residues.. N- and O-glycosylated.. Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.. It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.. Phosphorylation sites are present in the extracellular medium.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
See full target information Vitronectin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell biology international : PubMed38654431

2024

Vitronectin promotes insulin resistance in trophoblast cells by activating JNK in gestational diabetes mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Yuejun Ju,Ting Shen,Zhanhong Guo,Yinghong Kong,Yun Huang,Ji Hu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Proteins & Peptides

AB92683

Native Human Vitronectin/S-Protein

proteins-peptides

native-human-vitronectin-s-protein-ab92683

0

(0 reviews)

Alternative Product
Proteins & Peptides

AB153797

Recombinant Human Vitronectin/S-Protein

proteins-peptides

recombinant-human-vitronectin-s-protein-ab153797

0

(0 reviews)

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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