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AB127291

Recombinant Human WASH complex subunit 4 protein (His-DHFR tag N-Terminus)

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Recombinant Human WASH complex subunit 4 protein (His-DHFR tag N-Terminus) is a Human Fragment protein, in the 760 to 918 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

KIAA1033, WASHC4, WASH complex subunit 4, Strumpellin and WASH-interacting protein, WASH complex subunit SWIP, SWIP

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His-DHFR tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q2M389

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

Storage buffer

Constituents: 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Complementary Products

Primary Antibodies

AB111109

Anti-WASH complex subunit 4 antibody

  • 4
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labeled as WASH complex subunit 7
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"19.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":918,"aminoAcidStart":760,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q2M389","tags":[{"tag":"His-DHFR","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Specifications

Form

Lyophilized

Additional notes

Purified via His tag

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General info

Function

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Sequence similarities

Belongs to the SWIP family.

Subcellular localisation

Early endosome

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Product protocols

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Target data

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
See full target information WASHC4
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Product promise

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