Recombinant Human WDR5B protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A T K E S R D A K A Q L A L S S S A N Q S K E V P E N P N Y A L K C T L V G H T E A V S S V K F S P N G E W L A S S S A D R L I I I W G A Y D G K Y E K T L Y G H N L E I S D V A W S S D S S R L V S A S D D K T L K L W D V R S G K C L K T L K G H S N Y V F C C N F N P P S N L I I S G S F D E T V K I W E V K T G K C L K T L S A H S D P V S A V H F N C S G S L I V S G S Y D G L C R I W D A A S G Q C L K T L V D D D N P P V S F V K F S P N G K Y I L T A T L D N T L K L W D Y S R G R C L K T Y T G H K N E K Y C I F A N F S V T G G K W I V S G S E D N L V Y I W N L Q T K E I V Q K L Q G H T D V V I S A A C H P T E N L I A S A A L E N D K T I K L W M S N H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
Alternative names
WD repeat-containing protein 5B, WDR5B
Recommended products
Recombinant Human WDR5B protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q86VZ2-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A T K E S R D A K A Q L A L S S S A N Q S K E V P E N P N Y A L K C T L V G H T E A V S S V K F S P N G E W L A S S S A D R L I I I W G A Y D G K Y E K T L Y G H N L E I S D V A W S S D S S R L V S A S D D K T L K L W D V R S G K C L K T L K G H S N Y V F C C N F N P P S N L I I S G S F D E T V K I W E V K T G K C L K T L S A H S D P V S A V H F N C S G S L I V S G S Y D G L C R I W D A A S G Q C L K T L V D D D N P P V S F V K F S P N G K Y I L T A T L D N T L K L W D Y S R G R C L K T Y T G H K N E K Y C I F A N F S V T G G K W I V S G S E D N L V Y I W N L Q T K E I V Q K L Q G H T D V V I S A A C H P T E N L I A S A A L E N D K T I K L W M S N H
- Accession
- Q86VZ2
- Protein length
- Full Length
- Amino acids
- 1 to 330
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
- Sequence similarities
Belongs to the WD repeat WDR5/wds family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
WDR5B also known as WD repeat-containing protein 5B is a protein involved in chromatin modification. This protein has a molecular mass of approximately 38 kDa. It expresses in various tissues with notable expression in reproductive tissues and certain types of cancer cells. WDR5B has the ability to bind to other proteins through its WD40 repeats facilitating protein-protein interactions essential for its function.
- Biological function summary
WDR5B participates in the regulation of gene expression. It acts as a component of chromatin remodeling complexes assisting in the modification of histone proteins. This function suggests that WDR5B plays a role in epigenetic regulation impacting processes like cell proliferation and differentiation. In these complexes WDR5B enables the formation of stable structures that modify the accessibility of transcriptional machinery to DNA.
- Pathways
WDR5B plays important roles in the regulation of the cell cycle and DNA damage response pathways. It interacts with proteins such as MYC and MLL1 influencing processes that control cell division and the maintenance of genomic integrity. Through these pathways WDR5B contributes to the regulation of genes that ensure proper cell cycle progression and repair of damaged DNA.
- Associated diseases and disorders
Researchers have shown interest in WDR5B due to its association with cancer and developmental disorders. WDR5B's interaction with MYC proteins can enhance oncogenic pathways promoting tumorigenesis in certain cancers. Furthermore dysregulation of WDR5B can be linked to developmental disorders where abnormal chromatin remodeling affects gene expression patterns important for normal development. Researchers continue to explore WDR5B's potential as a therapeutic target in these diseases.
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1 product image
SDS-PAGE - Recombinant Human WDR5B protein (ab162780)
ab162780 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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