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AB162780

Recombinant Human WDR5B protein (GST tag N-Terminus)

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Recombinant Human WDR5B protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

WD repeat-containing protein 5B, WDR5B

1 Images
SDS-PAGE - Recombinant Human WDR5B protein (AB162780)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human WDR5B protein (AB162780)

ab162780 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86VZ2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSNH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":330,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86VZ2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR5B also known as WD repeat-containing protein 5B is a protein involved in chromatin modification. This protein has a molecular mass of approximately 38 kDa. It expresses in various tissues with notable expression in reproductive tissues and certain types of cancer cells. WDR5B has the ability to bind to other proteins through its WD40 repeats facilitating protein-protein interactions essential for its function.
Biological function summary

WDR5B participates in the regulation of gene expression. It acts as a component of chromatin remodeling complexes assisting in the modification of histone proteins. This function suggests that WDR5B plays a role in epigenetic regulation impacting processes like cell proliferation and differentiation. In these complexes WDR5B enables the formation of stable structures that modify the accessibility of transcriptional machinery to DNA.

Pathways

WDR5B plays important roles in the regulation of the cell cycle and DNA damage response pathways. It interacts with proteins such as MYC and MLL1 influencing processes that control cell division and the maintenance of genomic integrity. Through these pathways WDR5B contributes to the regulation of genes that ensure proper cell cycle progression and repair of damaged DNA.

Researchers have shown interest in WDR5B due to its association with cancer and developmental disorders. WDR5B's interaction with MYC proteins can enhance oncogenic pathways promoting tumorigenesis in certain cancers. Furthermore dysregulation of WDR5B can be linked to developmental disorders where abnormal chromatin remodeling affects gene expression patterns important for normal development. Researchers continue to explore WDR5B's potential as a therapeutic target in these diseases.
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Specifications

Form

Liquid

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General info

Function

May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

Sequence similarities

Belongs to the WD repeat WDR5/wds family.

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Product protocols

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Target data

May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
See full target information WDR5B
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