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AB166176

Recombinant Human WDR62 protein

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Recombinant Human WDR62 protein is a Human Full Length protein, in the 1 to 630 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C19orf14, WDR62, WD repeat-containing protein 62

1 Images
SDS-PAGE - Recombinant Human WDR62 protein (AB166176)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human WDR62 protein (AB166176)

ab166176 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O43379

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLLPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGSTASLLEPTSGALGLFQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":630,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43379","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR62 also known as WD repeat-containing protein 62 is a protein with a molecular mass of approximately 152 kDa. It localizes predominantly in the cytoplasm and the spindle poles of dividing cells. The protein contains several WD40 repeats which are motifs critical for protein-protein interactions. WDR62 is expressed in various tissues including the brain suggesting a significant function in neural development.
Biological function summary

WDR62 plays an essential role in neurogenesis by influencing cell proliferation and differentiation. It is a component of the spindle assembly complex ensuring proper chromosomal segregation during cell division. The protein is particularly active during mitosis where it participates in establishing spindle pole organization. Proper function of WDR62 is necessary for maintaining the integrity of the neuronal population in the developing brain.

Pathways

Spindle assembly and mitotic progression heavily involve WDR62. It interacts with Aurora A kinase an important player in the mitotic checkpoint pathway allowing accurate chromosome alignment and segregation. WDR62 also associates with c-Jun N-terminal kinase (JNK) signaling which impacts cell cycle regulation and apoptosis. These interactions suggest that WDR62 plays a role in ensuring normal cell division and viability.

Mutations in WDR62 often lead to microcephaly a condition characterized by reduced brain size and intellectual disability. This link highlights the protein's critical function in brain development. Additionally aberrations in WDR62 might contribute to epileptic syndromes reflecting its involvement in neuronal health. In these disorders it interacts with proteins such as ASPM and CEP152 which are also implicated in microcephaly and cortical malformations.
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Specifications

Form

Liquid

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General info

Function

Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed : 20729831, PubMed : 20890278). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed : 26297806).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed : 20729831, PubMed : 20890278). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed : 26297806).
See full target information WDR62
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