Recombinant Human WDR77 protein (Tagged)
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Recombinant Human WDR77 protein (Tagged) is a Human Fragment protein, in the 1 to 312 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
MEP50, WD45, HKMT1069, Nbla10071, WDR77, Methylosome protein WDR77, Androgen receptor cofactor p44, Methylosome protein 50, WD repeat-containing protein 77, p44/Mep50, MEP-50
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human WDR77 protein (Tagged) (AB226226)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab226226 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) WDR77.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human WDR77 protein (Tagged) (AB226226)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab226226 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) WDR77.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human WDR77 protein (Tagged) (AB226226)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
WDR77 interacts with the protein arginine methyltransferase 5 (PRMT5) and contributes to the assembly and stabilization of methyltransferase complexes. This role is essential for its participation in the methylation of arginine residues on histones and other proteins which regulates gene expression. WDR77 influences cell proliferation and differentiation by modulating these processes especially in germ cells and prostate epithelial cells.
Pathways
WDR77 is an important player in the transcriptional repression pathway affecting histone modification. It connects intimately with important pathways like the PI3K/AKT signaling and cell cycle regulation. Through its interaction with PRMT5 WDR77 takes part in regulatory networks impacting gene silencing chromatin remodeling and the overall gene expression mechanism. The involvement of WDR77 in these pathways emphasizes its relationship with PRMT5 and other methylation-associated proteins.
Specifications
Form
Liquid
General info
Function
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed : 11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed : 23071334).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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