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AB195164

Recombinant Human WDR9/BRWD1 protein

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Recombinant Human WDR9/BRWD1 protein is a Human Fragment protein, in the 1308 to 1436 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

C21orf107, WDR9, BRWD1, Bromodomain and WD repeat-containing protein 1, WD repeat-containing protein 9

1 Images
SDS-PAGE - Recombinant Human WDR9/BRWD1 protein (AB195164)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human WDR9/BRWD1 protein (AB195164)

4-20% SDS-PAGE using 3 μg ab195164 stained with coomassie (lane 1). Lane 2 is protein marker.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NSI6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as WDR9

This product was previously labelled as WDR9

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Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSIRATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQ","proteinLength":"Fragment","predictedMolecularWeight":"42.08 kDa","actualMolecularWeight":null,"aminoAcidEnd":1436,"aminoAcidStart":1308,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NSI6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The WDR9/BRWD1 protein is also known by its alternate name BRWD1 and has a molecular mass of approximately 250 kDa. This protein shows expression in various tissues with higher levels observed in testis and certain brain regions. WDR9/BRWD1 is a member of the WD-repeat protein family and contains two bromodomains. Mechanically it plays a role in mediating protein-protein interactions aiding in chromatin organization and gene regulation.
Biological function summary

WDR9/BRWD1 functions in regulating transcriptional processes and is often part of nuclear chromatin complexes. It participates in gene expression important for spermatogenesis and neuronal differentiation. This protein interacts with other chromatin-modifying proteins contributing to the alteration of chromatin states and affecting cellular programs.

Pathways

Different regulatory and developmental processes involve WDR9/BRWD1. The protein plays roles within chromatin remodeling pathways. It engages with pathways such as histone modification and transcriptional regulation working alongside proteins like histones and other transcription factors which helps coordinate the accessibility of transcriptional machinery to DNA.

Abnormal WDR9/BRWD1 expression or mutations have connections to neurological and reproductive conditions. Studies link its dysregulation to intellectual disabilities and fertility issues. Its association with chromatin-modifying proteins implicates it in diseases where gene expression regulation plays a role such as certain cognitive disorders.
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Specifications

Form

Liquid

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General info

Function

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
See full target information BRWD1
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