Recombinant Human WFDC12 protein is a Human Full Length protein, in the 24 to 111 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S V K E G I E K A G V C P A D N V R C F K S D P P Q C H T D Q D C L G E R K C C Y L H C G F K C V I P V K E L E E G G N K D E D V S R P Y P E P G W E A K C P G S S S T R C P Q K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Antibacterial protein. Putative acid-stable proteinase inhibitor.
Alternative names
C20orf122, WAP2, UNQ544/PRO844, WFDC12, WAP four-disulfide core domain protein 12, Putative protease inhibitor WAP12, Whey acidic protein 2
Recommended products
Recombinant Human WFDC12 protein is a Human Full Length protein, in the 24 to 111 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8WWY7-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S V K E G I E K A G V C P A D N V R C F K S D P P Q C H T D Q D C L G E R K C C Y L H C G F K C V I P V K E L E E G G N K D E D V S R P Y P E P G W E A K C P G S S S T R C P Q K
- Accession
- Q8WWY7
- Protein length
- Full Length
- Predicted molecular weight
- 12.1 kDa
- Amino acids
- 24 to 111
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab177599 was purified using conventional chromatography.
General info
- Function
Antibacterial protein. Putative acid-stable proteinase inhibitor.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
WFDC12 also known as WAP four-disulfide core domain protein 12 is a member of the WFDC family of proteins characterized by their WAP (whey acidic protein) domains. This protein weighs approximately 27 kDa. Researchers have identified its expression predominantly in the male reproductive tract particularly in epididymal tissues and in certain skin tissues. Due to its presence in these tissues the protein could play a role in specific local physiological processes.
- Biological function summary
WFDC12 functions as an antimicrobial protein with inhibitory effects against certain pathogens. It does not form part of any known large multiprotein complexes but works individually to exert its effects. Its antimicrobial activity suggests a protective role for WFDC12 in defending its expression sites against microbial invasion helping maintain tissue health in these regions.
- Pathways
WFDC12 operates in the context of immune defense mechanisms particularly those related to antimicrobial response pathways. In these pathways WFDC12 associates with other antimicrobial and defensive proteins such as lactoferrin which also provides protection against microbial threats. It does not engage directly in major signaling cascades but contributes to broader immune responses that complement these pathways.
- Associated diseases and disorders
WFDC12 relevance emerges in conditions involving abnormal microbial activities such as infections of the reproductive tract and certain skin infections. The protein's role in controlling microbial populations links it to diseases where immune defense is compromised or dysregulated. WFDC12 may interact with S100A7 another protein in the skin in contexts where inflammation and microbial attack occur highlighting its protective involvement in disease states.
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1 product image
SDS-PAGE - Recombinant Human WFDC12 protein (ab177599)
15% SDS-PAGE analysis of 3μg ab177599.
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