Recombinant Human WFDC2 Protein (His tag) is a Human Full Length protein, in the 31 to 124 aa range, expressed in HEK 293, with >=95% purity, >= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS.
>=95% HPLC
>= 0.005 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE, MS
No
E K T G V C P E L Q A D Q N C T Q E C V S D S E C A D N L K C C S A G C A T F C S L P N D K E G S C P Q V N I N F P Q L G L C R D Q C Q V D S Q C P G Q M K C C R N G C G K V S C V T P N F
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Broad range protease inhibitor.
HE4, WAP5, WFDC2, HE4, WAP5, WAP four-disulfide core domain protein 2, Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5
Recombinant Human WFDC2 Protein (His tag) is a Human Full Length protein, in the 31 to 124 aa range, expressed in HEK 293, with >=95% purity, >= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS.
>=95% HPLC
>= 0.005 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE, MS
No
Yes
Human
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
E K T G V C P E L Q A D Q N C T Q E C V S D S E C A D N L K C C S A G C A T F C S L P N D K E G S C P Q V N I N F P Q L G L C R D Q C Q V D S Q C P G Q M K C C R N G C G K V S C V T P N F
Full Length
11.5 kDa
11.5 kDa
31 to 124
Recombinant
His tag C-Terminus
Lyophilized
Broad range protease inhibitor.
Blue Ice
Ambient
Ambient
This supplementary information is collated from multiple sources and compiled automatically.
Human Epididymis Protein 4 (HE4) also known as WAP four-disulfide core domain protein 2 (WFDC2) is a small glycoprotein of approximately 13 kDa. HE4 is most highly expressed in the epithelial cells of reproductive tissues like the epididymis but also in tissues such as the respiratory and urogenital tracts. HE4 is secreted into the extracellular space where it functions and is found in normal range in different body fluids. This secreted protein has gained attention due to its use in various diagnostic tests such as the HE4 test and HE4 assay utilizing HE4 antibodies.
HE4 participates in innate immune response and epithelial cell protection. HE4 protein plays a role in the modulation of antiprotease activity as it is involved in inhibiting serine proteases. It is not part of a larger protein complex but interacts with multiple protease signaling pathways. HE4 is often studied for its role in modulating protein activity at epithelial barriers contributing to tissue homeostasis and protective mechanisms against infections.
HE4 interacts within signaling cascades such as the innate immune pathways and extracellular matrix organization. It links to proteins within these pathways like serine proteases and other WFDC family proteins. HE4 influences protease activity regulation an essential component of tissue remodeling and inflammatory response impacting overall pathway dynamics.
HE4 has strong associations with ovarian cancer and endometrial cancer. Its overexpression in these malignancies makes it a valuable biomarker for disease diagnosis and prognosis. HE4 interacts with cancer-related proteins such as CA125 enhancing its utility in combinatory diagnostic approaches. The HE4 test and HE4 ELISA kit price underline its significance in clinical settings for monitoring these cancers where timely detection influences treatment outcomes.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
SDS-page analysis of ab313361
Mass determination by ESI-TOF. Predicted MW is 11545.05(+/- 10Da by ESI-TOF). Observed MW is 11543.63.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com