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Recombinant Human WFDC2 Protein (His tag) is a Human Full Length protein, in the 31 to 124 aa range, expressed in HEK 293, with >=95% purity, >= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS.

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Images

SDS-PAGE - Recombinant Human WFDC2 Protein (His tag) (AB313361), expandable thumbnail
  • Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (AB313361), expandable thumbnail

Key facts

Purity

>=95% HPLC

Endotoxin level

>= 0.005 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, MS

Biologically active

No

Amino acid sequence

E K T G V C P E L Q A D Q N C T Q E C V S D S E C A D N L K C C S A G C A T F C S L P N D K E G S C P Q V N I N F P Q L G L C R D Q C Q V D S Q C P G Q M K C C R N G C G K V S C V T P N F

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

MS

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Broad range protease inhibitor.

Alternative names

Recommended products

Recombinant Human WFDC2 Protein (His tag) is a Human Full Length protein, in the 31 to 124 aa range, expressed in HEK 293, with >=95% purity, >= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS.

Key facts

Purity

>=95% HPLC

Endotoxin level

>= 0.005 EU/µg

Expression system

HEK 293 cells

Applications

SDS-PAGE, MS

Accession
Q14508-1
Animal free

Yes

Species

Human

Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

Sequence info

Amino acid sequence

E K T G V C P E L Q A D Q N C T Q E C V S D S E C A D N L K C C S A G C A T F C S L P N D K E G S C P Q V N I N F P Q L G L C R D Q C Q V D S Q C P G Q M K C C R N G C G K V S C V T P N F

Accession

Q14508

Protein length

Full Length

Predicted molecular weight

11.5 kDa

Amino acids

31 to 124

Nature

Recombinant

Tags

His tag C-Terminus

Specifications

Form

Lyophilized

General info

Function

Broad range protease inhibitor.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Human Epididymis Protein 4 (HE4) also known as WAP four-disulfide core domain protein 2 (WFDC2) is a small glycoprotein of approximately 13 kDa. HE4 is most highly expressed in the epithelial cells of reproductive tissues like the epididymis but also in tissues such as the respiratory and urogenital tracts. HE4 is secreted into the extracellular space where it functions and is found in normal range in different body fluids. This secreted protein has gained attention due to its use in various diagnostic tests such as the HE4 test and HE4 assay utilizing HE4 antibodies.

Biological function summary

HE4 participates in innate immune response and epithelial cell protection. HE4 protein plays a role in the modulation of antiprotease activity as it is involved in inhibiting serine proteases. It is not part of a larger protein complex but interacts with multiple protease signaling pathways. HE4 is often studied for its role in modulating protein activity at epithelial barriers contributing to tissue homeostasis and protective mechanisms against infections.

Pathways

HE4 interacts within signaling cascades such as the innate immune pathways and extracellular matrix organization. It links to proteins within these pathways like serine proteases and other WFDC family proteins. HE4 influences protease activity regulation an essential component of tissue remodeling and inflammatory response impacting overall pathway dynamics.

Associated diseases and disorders

HE4 has strong associations with ovarian cancer and endometrial cancer. Its overexpression in these malignancies makes it a valuable biomarker for disease diagnosis and prognosis. HE4 interacts with cancer-related proteins such as CA125 enhancing its utility in combinatory diagnostic approaches. The HE4 test and HE4 ELISA kit price underline its significance in clinical settings for monitoring these cancers where timely detection influences treatment outcomes.

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2 product images

  • SDS-PAGE - Recombinant Human WFDC2 Protein (His tag) (ab313361), expandable thumbnail

    SDS-PAGE - Recombinant Human WFDC2 Protein (His tag) (ab313361)

    SDS-page analysis of ab313361

  • Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (ab313361), expandable thumbnail

    Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (ab313361)

    Mass determination by ESI-TOF. Predicted MW is 11545.05(+/- 10Da by ESI-TOF). Observed MW is 11543.63.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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