JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276451

Recombinant Human WFIKKN2 protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human WFIKKN2 protein (His tag) is a Human Full Length protein, in the 1 to 576 aa range, expressed in HEK 293 cells, with >96%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

GASP1, WFIKKNRP, UNQ9235/PRO31996, WFIKKN2, Growth and differentiation factor-associated serum protein 1, WFIKKN-related protein, GASP-1, hGASP-1

1 Images
SDS-PAGE - Recombinant Human WFIKKN2 protein (His tag) (AB276451)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human WFIKKN2 protein (His tag) (AB276451)

SDS-PAGE analysis of ab276451

Key facts

Purity

>96% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8TEU8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB192295

Recombinant Human REG3G protein

  • 0
  • 0
Primary Antibodies

AB302891

Anti-PKC theta/PRKCQ antibody [27/PKC theta]

Recombinant|Trial Size

Immunoprecipitation - Anti-PKC theta/PRKCQ antibody [27/PKC theta] (AB302891)

  • 0
  • 0
Proteins & Peptides

AB271794

Recombinant Human Wee1 protein (DDDDK tag N-Terminus)

SDS-PAGE - Recombinant Human Wee1 protein (DDDDK tag N-Terminus) (AB271794)

  • 0
  • 0
Proteins & Peptides

AB60838

Recombinant human PRKACG protein

Functional Studies - Recombinant human PRKACG protein (AB60838)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"linker":null,"sequence":"MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQSTCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH","proteinLength":"Full Length","predictedMolecularWeight":"61.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":576,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8TEU8","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The WFIKKN2 protein also known as WAP Follistatin/Kazal Immunoglobulin Kunitz and Netrin domain-containing 2 is a multifunctional inhibitor protein with an approximate mass of 50 kDa. It acts by binding to and inhibiting members of the transforming growth factor-beta (TGF-beta) superfamily. Researchers find WFIKKN2 expressed in tissues such as liver and skeletal muscle supporting its role in different physiological processes.
Biological function summary

WFIKKN2 inhibits signaling pathways associated with muscle growth and development. It does not form part of a larger complex but acts independently to exert its effects. By modulating signaling WFIKKN2 impacts cell growth differentiation and repair contributing to maintaining tissue homeostasis.

Pathways

WFIKKN2 interacts with myostatin and growth differentiation factor 11 (GDF11) both vital components of the TGF-beta pathway. These interactions place it significantly in pathways regulating muscle mass and aging processes. Through these connections WFIKKN2 influences the balance between muscle breakdown and growth which is essential for organismal development and metabolic regulation.

WFIKKN2 affects conditions such as muscular dystrophy and sarcopenia. In muscular dystrophy abnormal regulation of myostatin a protein inhibited by WFIKKN2 plays a critical role in disease progression. Similarly in sarcopenia the age-related loss of muscle mass changes in the myostatin pathway influence muscle degradation. Understanding WFIKKN2's role opens possibilities for therapeutic interventions targeting these specific protein interactions.
style
left-column

General info

Function

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).

Sequence similarities

Belongs to the WFIKKN family.

style
left-column

Product protocols

style
left-column

Target data

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).
See full target information WFIKKN2
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com