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AB269159

Recombinant Human WISP2 protein

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Recombinant Human WISP2 protein is a Human Full Length protein, in the 24 to 250 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CT58, CTGFL, WISP2, UNQ228/PRO261, CCN5, CCN family member 5, Connective tissue growth factor-like protein, Connective tissue growth factor-related protein 58, WNT1-inducible-signaling pathway protein 2, CTGF-L, WISP-2

1 Images
SDS-PAGE - Recombinant Human WISP2 protein (AB269159)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human WISP2 protein (AB269159)

SDS-PAGE analysis of ab269159 at 1ug/lane under (-) non-reducing and (+) reducing conditions. 4-20% Tris glycine gel. Stained with coomassie blue.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O76076

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute at 0.1 mg/mL in 10 mM acetic acid

Storage buffer

Constituents: 0.1% Trifluoroacetic acid

storage-buffer

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Primary Antibodies

AB123375

Anti-WISP2 antibody

Western blot - Anti-WISP2 antibody (AB123375)

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Bioactive

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF","proteinLength":"Full Length","predictedMolecularWeight":"27 kDa","actualMolecularWeight":null,"aminoAcidEnd":250,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O76076","tags":[]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WISP2 also known as WNT1-inducible signaling pathway protein 2 or CCN5 is a protein that weighs approximately 29 kDa. This protein belongs to the CCN family which includes connective tissue growth factor and nephroblastoma overexpressed gene. WISP2 expression appears in various human tissues particularly in the liver lung and breast tissues. It is known to engage in cellular processes often impacting cell growth and differentiation due to its role in signaling pathways.
Biological function summary

Researchers observe WISP2’s significant role in cell proliferation migration and anti-apoptotic activities. It is known to not be part of a larger protein complex. This protein influences cell behavior and works in modulating functions related to the extracellular matrix. This modulation aids cellular restructuring and organization which are essential processes in tissue repair and development.

Pathways

Studies demonstrate that WISP2 plays a role in the Wnt signaling and PI3K/Akt pathways. The presence of WISP2 in these pathways allows it to control signals that regulate cell growth and survival. Within these pathways WISP2 interacts with several proteins including beta-catenin and AKT1 which help in transmitting signals from cell surface receptors to the DNA in the nucleus influencing gene expression and cellular responses.

WISP2 shows relevance in cancer and fibrosis. Researchers study its expression in breast cancer noting that it impacts tumor development and progression by interacting with other proteins like estrogen receptor-alpha (ERα). Moreover in the context of fibrosis WISP2 may influence fibrotic processes possibly involving connective tissue growth factor (CTGF) which contributes to tissue scarring and thickening through extracellular matrix production.
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Specifications

Form

Lyophilized

Additional notes

nan

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General info

Function

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

Sequence similarities

Belongs to the CCN family.

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Product protocols

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Target data

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
See full target information CCN5
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Product promise

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