Recombinant human WISP3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WISP3 also known as CCN6 is a protein with a mass of approximately 39 kDa. It belongs to the CCN family of proteins which are involved in diverse cellular processes. WISP3 is primarily expressed in cartilage and connective tissues such as bone and skin. This protein interacts with growth factors and other signaling molecules influencing cellular growth and maintenance. WISP3's mechanical role involves binding to extracellular matrix components which affects cell adhesion and communication.

Biological function summary

WISP3 functions as an important modulator of cartilage homeostasis and matrix production. It takes part in processes that regulate cartilage integrity and interacts with other extracellular proteins to maintain the physical properties of connective tissues. One of its roles includes modulating interactions with the insulin-like growth factor (IGF) binding proteins. These interactions support tissue structural integrity and cellular communication essential for development and repair mechanisms.

Pathways

WISP3 participates in the regulation of the Wnt signaling pathway. This pathway plays an important role in chondrogenesis and osteogenesis processes vital for bone and cartilage development. WISP3 influences the activity of key proteins within this pathway such as Wnt and Frizzled to modulate gene expression. It also interacts with proteins like beta-catenin which are pivotal to these signaling cascades therefore contributing to tissue specification and differentiation processes.

WISP3 mutations are associated with Progressive Pseudorheumatoid Dysplasia (PPD) and have connections to conditions affecting skeletal development. PPD is a disorder characterized by cartilage degeneration leading to joint pain and stiffness. WISP3's interaction with IGF-related proteins is critical in these conditions as dysregulation can lead to improper tissue development and homeostasis. Studies also link abnormal WISP3 activity to osteoarthritis where its altered expression might contribute to the disease pathology by affecting cartilage cell signaling and matrix production.