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AB289784

Recombinant Human Wnt10a protein

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Recombinant Human Wnt10a protein is a Human Full Length protein, in the 36 to 417 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

View Alternative Names

Protein Wnt-10a, WNT10A

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SDS-PAGE - Recombinant Human Wnt10a protein (AB289784)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Wnt10a protein (AB289784)

SDS-PAGE analysis of ab289784

Key facts

Purity

>90% SDS-PAGE

Expression system

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9GZT5

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 2.9% Sodium chloride, 0.24% Tris

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK","proteinLength":"Full Length","predictedMolecularWeight":"44.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":417,"aminoAcidStart":36,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"Q9GZT5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Wnt10a also known as Wingless-type MMTV integration site family member 10A is a protein that plays an important role in cellular signaling. This protein has a molecular mass of approximately 46 kDa. Wnt10a is expressed in various tissues including skin teeth and hair follicles where it is involved in mediating several cellular processes. The protein participates in signaling events by binding to specific receptors on the cell surface initiating a cascade of intracellular activities that influence development and cell differentiation.
Biological function summary

The Wnt10a protein is involved in the regulation of development and differentiation of ectodermal organs. It acts as a ligand in the Wnt signaling pathway which is a critical component of developmental processes. Wnt10a does not form complexes with others but binds to Frizzled receptors on the cell surface to propagate signals inside the cell. These signaling events guide proper formation and functioning of skin hair teeth and certain other structures influencing tissue maintenance and growth.

Pathways

Wnt10a plays a major role in the Wnt signaling pathways specifically the canonical Wnt/β-catenin pathway. This pathway is essential for gene transcription regulation and Wnt10a activates this through interaction with Frizzled and LRP co-receptors. Wnt10a's function is particularly related to the control of gene expression necessary for embryonic development and cell proliferation often working alongside other Wnt family proteins such as Wnt10b to regulate these pathways.

Wnt10a has associations with ectodermal dysplasia and tooth agenesis. Mutations in the Wnt10a gene can result in developmental disorders affecting skin hair and teeth due to its role in ectodermal organ formation. Additionally reduced Wnt10a function is linked with conditions such as osteoporosis where bone density is compromised. The protein’s interaction with other Wnt proteins in these disorders highlights the intricate balance of the Wnt signaling network in maintaining tissue and organ health.
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Specifications

Form

Lyophilized

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General info

Function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed : 17847007, PubMed : 28589954). Required for normal tooth development (PubMed : 17847007, PubMed : 28589954, PubMed : 29178643). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed : 28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed : 28589954). Required for normal hair follicle function (PubMed : 28589954).

Sequence similarities

Belongs to the Wnt family.

Post-translational modifications

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

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Product protocols

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Target data

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed : 17847007, PubMed : 28589954). Required for normal tooth development (PubMed : 17847007, PubMed : 28589954, PubMed : 29178643). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed : 28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed : 28589954). Required for normal hair follicle function (PubMed : 28589954).
See full target information Protein Wnt-10a
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Primary Antibodies

AB106522

Anti-Wnt10a antibody

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