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AB289754

Recombinant Human Wnt2b protein

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Recombinant Human Wnt2b protein is a Human Full Length protein, in the 1 to 391 aa range, expressed in Cell free, with >90%, suitable for SDS-PAGE.

View Alternative Names

WNT13, WNT2B, Protein Wnt-2b, Protein Wnt-13

1 Images
SDS-PAGE - Recombinant Human Wnt2b protein (AB289754)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Wnt2b protein (AB289754)

SDS-PAGE analysis of ab289754

Key facts

Purity

>90% SDS-PAGE

Expression system

Cell free

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q93097

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.12% Tris, 0.037% Ethylenediaminetetraacetic acid, disodium, dihydrate

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLRPGGAEEAAQLPLRRASAPVPVPSPAAPDGSRASARLGLACLLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT","proteinLength":"Full Length","predictedMolecularWeight":"59.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":391,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q93097","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Wnt2b also known as Wingless-type MMTV integration site family member 2B plays a mechanical role as a ligand in the Wnt signaling pathway. The protein weighs around 41 kDa and is expressed in various tissues including the brain lung and reproductive organs. As a signaling molecule Wnt2b binds to receptor complexes on cell surfaces initiating intracellular signaling cascades that regulate cellular processes.
Biological function summary

The Wnt2b protein influences embryonic development and cell fate decisions. It engages in cellular proliferation differentiation and migration. Wnt2b is a component of the Wnt signaling protein family known for forming signaling complexes with Frizzled receptors. Its role in establishing cell polarity and maintaining stem cell pluripotency makes it important for tissue development and repair.

Pathways

Wnt2b contributes to Wnt/β-catenin and non-canonical Wnt signaling pathways. Wnt/β-catenin signaling is vital for gene transcription regulation where Wnt2b partners with proteins like β-catenin and Axin to modulate these pathways. Non-canonical Wnt signaling impacts cellular architecture and movement without involving β-catenin linking Wnt2b to other proteins through alternative signaling routes.

Wnt2b-related disruptions often tie to cancer and bone density disorders. Aberrant Wnt2b expression connects to cancers such as colorectal cancer linking it with other related Wnt family members and tumor suppressor proteins like APC. Alterations in Wnt2b's function may also associate with bone density disorders by affecting osteoblast differentiation with implications for conditions like osteoporosis.
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Specifications

Form

Lyophilized

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General info

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.

Sequence similarities

Belongs to the Wnt family.

Post-translational modifications

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

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Product protocols

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Target data

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
See full target information WNT2B
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Complementary Products

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AB84080

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Bioactive

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Primary Antibodies

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Anti-Wnt2b antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt2b antibody (AB203225)

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Recombinant Human USP1 protein (Tagged)

SDS-PAGE - Recombinant Human USP1 protein (Tagged) (AB132351)

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Primary Antibodies

AB243739

Anti-SOX4 antibody [CL5665]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX4 antibody [CL5665] (AB243739)

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Product promise

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