Recombinant human Wnt7a protein is a Human Full Length protein, in the 32 to 349 aa range, expressed in HEK 293, with >80% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
L G A S I I C N K I P G L A P R Q R A I C Q S R P D A I I V I G E G S Q M G L D E C Q F Q F R N G R W N C S A L G E R T V F G K E L K V G S R E A A F T Y A I I A A G V A H A I T A A C T Q G N L S D C G C D K E K Q G Q Y H R D E G W K W G G C S A D I R Y G I G F A K V F V D A R E I K Q N A R T L M N L H N N E A G R K I L E E N M K L E C K C H G V S G S C T T K T C W T T L P Q F R E L G Y V L K D K Y N E A V H V E P V R A S R N K R P T F L K I K K P L S Y R K P M D T D L V Y I E K S P N Y C E E D P V T G S V G T Q G R A C N K T A P Q A S G C D L M C C G R G Y N T H Q Y A R V W Q C N C K F H W C C Y V K C N T C S E R T E M Y T C K
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).
Protein Wnt-7a, WNT7A
Recombinant human Wnt7a protein is a Human Full Length protein, in the 32 to 349 aa range, expressed in HEK 293, with >80% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
The purity of ab116171 is greater than 80% by SDS-PAGE gel and HPLC analyses.
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).
Belongs to the Wnt family.
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Wnt7a also known as Wingless-type MMTV integration site family member 7A is a protein involved in various cellular processes. It has a molecular mass of approximately 39 kDa and is expressed in several tissues including the brain lungs and kidneys. Mechanically Wnt7a acts as a signaling molecule that binds to frizzled receptors on cell surfaces initiating downstream signaling cascades that result in the transcriptional regulation of target genes.
This protein plays a critical role in the regulation of developmental processes including cell proliferation differentiation and migration. Wnt7a is part of the Wnt signaling pathway which is a complex network of proteins known for its involvement in embryonic development and regulation of cell fate decisions. The pathway contributes to the proper formation of tissues and organs and maintains cellular homeostasis.
Wnt7a is significantly involved in the canonical Wnt/β-catenin signaling pathway as well as the planar cell polarity pathway. In the canonical pathway Wnt7a influences the stabilization and translocation of β-catenin to the nucleus promoting transcription of target genes. It also interacts with other Wnt proteins like Wnt3a and different frizzled receptors playing roles in various cell signaling events and modulating cellular communication.
Wnt7a is linked to limb malformation disorders such as Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. These conditions arise from mutations that affect the function of Wnt7a disrupting normal limb development. Additionally aberrant Wnt7a signaling has implications in cancer particularly in the modulation of tumor microenvironment and metastasis where altered interactions with proteins like β-catenin can contribute to oncogenic processes.
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