Recombinant Human WSB2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WSB2 also known as WD Repeat and SOCS Box-containing protein 2 weighs approximately 38 kDa. Mechanically WSB2 supports protein degradation and regulates ubiquitination. It presents ubiquitin ligase activity through interaction with other proteins marking them for degradation. You can find WSB2 widely expressed in various tissues including the brain kidney and heart.

Biological function summary

WSB2 plays a role in cellular processes related to protein homeostasis. It is part of a larger protein ubiquitination complex that includes other SOCS box-containing proteins. This complex facilitates targeted degradation of substrates contributing to cellular quality control. WSB2 influences cellular functions by managing levels of important regulatory proteins.

Pathways

WSB2 impacts processes like the JAK-STAT signaling and Wnt signaling pathways. In the JAK-STAT pathway WSB2 regulates signaling by modulating degradation of pathway components. It maintains cellular responses by ensuring the precise level and turnover of these proteins. Through these actions WSB2 has relationship with proteins like JAKs and KIT affecting cellular growth and communication.

WSB2 connects with cancer and neurological disorders. Dysregulation of its ubiquitination activity relates to tumor progression in cancers impacting proteins such as p53. In neurological contexts WSB2 may be involved in neurodegenerative disorders through its effect on protein aggregates. Its interaction with proteins involved in these pathways and conditions suggests potential relevance in disease mechanisms.