Recombinant Human XAGE1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

XAGE1 also known as GAGED2b is a cancer/testis antigen with a molecular mass of approximately 14 kDa. This protein is expressed primarily in testicular tissue and several types of cancer but shows limited expression in normal somatic tissues. XAGE1 locates in the cytoplasm of cells and may shuttle between cellular compartments depending on context. Researchers value XAGE1 as a biomarker due to its restricted expression pattern.

Biological function summary

XAGE1 impacts cell proliferation and immune response modulation. The protein does not form part of known complexes operating more as an individual player in cellular mechanisms. Its presence directly ties to cellular processes that control growth and survival suggesting roles in balancing cell cycle regulation and apoptosis. Elevated levels of XAGE1 can alter the cellular environment affecting various biological processes.

Pathways

The activity of XAGE1 integrates with growth signaling and immunogenic pathways. One critical pathway involves its role in modulating immune recognition of cancer cells. XAGE1 influences interactions within the tumor necrosis factor (TNF) superfamily potentially affecting the NF-kB signaling pathway. This relation suggests heightened expression of XAGE1 might further interactions with proteins like TNF-alpha and could modulate inflammatory responses or contribute to tumor immunity evasion.

XAGE1 has significant links to cancer particularly in lung and prostate malignancies. Enhanced expression in these cancers implies a potential influence on cancer progression and immune escape. Its connection to prostate cancer involves interactions with the androgen receptor pathway which is vital in disease development. Its expression patterns and regulatory roles can provide insights into cancer diagnostics and potential therapeutic targets.