Recombinant Human Xg blood group protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Xg blood group system comprises antigens located on the XG protein. The XG protein is an integral membrane protein with a molecular mass of approximately 48 kDa. It is expressed on the surface of red blood cells and is encoded by a gene on the X chromosome. The alternative name for the XG protein is CD99 which is also expressed on cells like lymphocytes and stromal cells indicating its widespread tissue distribution beyond erythrocytes.

Biological function summary

The XG protein is involved in cell adhesion and is known for its role in cell-to-cell interactions. Though not part of a larger complex it influences various cellular processes by facilitating communication between adjacent cells. These interactions play a significant role in the immune response and tissue integrity showing the importance of the XG protein in maintaining cellular configurations and communication.

Pathways

Several cellular signaling pathways involve the XG protein including cell migration and immune modulation pathways. The protein engages in cross-talk with other membrane proteins such as CD99 to regulate cellular adhesion and motility. These pathways facilitate cohesive cellular movement and interaction emphasizing their significance in processes like immune surveillance and tissue repair.

Irregularities in the XG protein expression or function may lead to conditions such as blood-related diseases or rare genetic disorders. Disruption in its expression associates with neurological disorders impacting the stability of neural cells. The XG protein also connects with abnormalities in the gene encoding CD99 which plays a part in autoimmune responses. Understanding these connections offers potential therapeutic targets for correcting such dysfunctions.