Recombinant Human YIF1B protein (denatured)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

YIF1B also known as YIP1 family member 1B is a protein that plays a role in the proper functioning of intracellular membrane systems. It is a member of the Yip1 family and weighs approximately 32 kDa. YIF1B is expressed in various tissues with significant expression noted in brain and lung tissues. This protein primarily localizes to the Golgi apparatus and endoplasmic reticulum indicating its involvement in protein trafficking and membrane dynamics.

Biological function summary

YIF1B contributes to maintaining the structure and function of the Golgi complex. It functions as part of the complex involved in vesicle-mediated transport interacting with other proteins to facilitate the movement and sorting of proteins and lipids. This protein is specifically involved in mediating interactions with small GTPases such as Rab proteins which regulate vesicular transport processes within cells.

Pathways

YIF1B integrates into important transport pathways including the secretory pathway and the ER to Golgi transport pathway. Within these pathways YIF1B functions alongside proteins like YIF1A and Rab GTPases to ensure efficient cargo delivery. This protein's role in membrane trafficking impacts the coordination and regulation of protein secretion and intracellular transport critical for maintaining cellular homeostasis.

Researchers have connected YIF1B to neurological disorders particularly neurodegenerative diseases. Dysregulation of YIF1B expression or function might influence diseases such as Alzheimer's due to its association with the misfolding and mistrafficking of proteins. It also connects to proteins involved in these diseases such as tau proteins indicating possible implications in the pathology of tauopathies. Proper YIF1B function is essential for neuronal health and disruptions can contribute to disease progression.