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AB276466

Recombinant Human YKL-39 protein (His tag)

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Recombinant Human YKL-39 protein (His tag) is a Human Full Length protein, in the 1 to 390 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Chitinase-3-like protein 2, Chondrocyte protein 39, YKL-39, CHI3L2

1 Images
SDS-PAGE - Recombinant Human YKL-39 protein (His tag) (AB276466)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human YKL-39 protein (His tag) (AB276466)

SDS-PAGE analysis of ab276466

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q15782

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGATTMDQKSLWAGVVVLLLLQGGSAYKLVCYFTNWSQDRQEPGKFTPENIDPFLCSHLIYSFASIENNKVIIKDKSEVMLYQTINSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTSRLEFINSIILFLRNHNFDGLDVSWIYPDQKENTHFTVLIHELAEAFQKDFTKSTKERLLLTAGVSAGRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPSSYYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETTVGAPASGPGAAGPITESSGFLAYYEICQFLKGAKITRLQDQQVPYAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMDDFTGKSCNQGPYPLVQAVKRSLGSL","proteinLength":"Full Length","predictedMolecularWeight":"42.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":390,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q15782","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

YKL-39 also known as Chitinase-3-like protein 2 is a member of the chitinase-like family of proteins with no enzymatic activity. This protein has a molecular weight of approximately 40 kDa. YKL-39 is mostly expressed in cartilage and actively secreted by chondrocytes the cells responsible for cartilage formation and maintenance. One can also detect lower levels of expression in other tissues including the synovium and skin indicating a potential role in joint health and skin biology.
Biological function summary

YKL-39 plays an important role in tissue remodeling and repair especially within the cartilage matrix. It does not form part of a large protein complex but interacts with other matrix proteins to help maintain structural integrity and support cellular responses to tissue damage. YKL-39 contributes to cell proliferation and has been found to affect inflammation pathways making it an important molecule in both normal physiological processes and in response to stress or injury.

Pathways

YKL-39 functions engage in critical roles within the extracellular matrix and inflammatory response pathways. Specifically it associates with the ECM as it relates to cartilage maintenance where it potentially interacts with other proteins such as YKL-40 another chitinase-like protein. YKL-39's involvement is significant in signaling cascades that mediate extracellular matrix homeostasis and modulate inflammation important for maintaining tissue structure and function.

YKL-39 relates closely to osteoarthritis and rheumatoid arthritis. The elevated expression of YKL-39 in cartilage from osteoarthritic patients suggests its involvement in cartilage degeneration and joint inflammation. During these disease processes YKL-39 may exhibit an association with matrix metalloproteinases proteins involved in the degradation of extracellular matrix components. Understanding YKL-39's function enables researchers to explore potential therapeutic targets for cartilage-related conditions.
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Specifications

Form

Lyophilized

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General info

Function

Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.

Sequence similarities

Belongs to the glycosyl hydrolase 18 family.

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Product protocols

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Target data

Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
See full target information CHI3L2
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