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AB165467

Recombinant Human ZBTB46 protein (GST tag N-Terminus)

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Recombinant Human ZBTB46 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 589 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

BTBD4, ZNF340, ZBTB46, Zinc finger and BTB domain-containing protein 46, BTB/POZ domain-containing protein 4, Zinc finger protein 340

1 Images
SDS-PAGE - Recombinant Human ZBTB46 protein (GST tag N-Terminus) (AB165467)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ZBTB46 protein (GST tag N-Terminus) (AB165467)

ab165467 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86UZ6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZNF358 protein (GST tag N-Terminus) (AB165455)

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SDS-PAGE - Recombinant Human TFIP11 protein (GST tag N-Terminus) (AB161769)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNNRKEDMEIASHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQPLWPGDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVRHITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDALLADDKDEEDSPRPRSPPGGPDKDFAWLS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":589,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86UZ6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB46 also known as zbtb46 Zfp405 or BTBD4 is a transcription factor with a molecular weight of approximately 60 kDa. It belongs to the BTB-ZF protein family and mainly expresses in dendritic cells and endothelial cells. This protein plays an important role in regulating gene expression by binding to DNA sequences through its zinc-finger domains. ZBTB46 serves as a specific marker for conventional dendritic cells which distinguishes them from other immune cells.
Biological function summary

The functioning of ZBTB46 involves the regulation of immune system responses and cellular development processes. ZBTB46 does not form a larger protein complex. Its activity impacts the maturation and function of certain immune cells especially those involved in presenting antigens to T cells. Through this regulation ZBTB46 influences various immune processes including inflammation and the maintenance of immune homeostasis helping to prevent excessive immune responses.

Pathways

ZBTB46 plays a role in the innate immune response and hematopoiesis. In the innate immune response it helps dictate the development of dendritic cells interacting with key proteins such as ID2 and E2-2. During hematopoiesis it guides the differentiation of multipotent progenitors toward specific cell lineages maintaining balanced production of immune cells. ZBTB46’s involvement in these pathways confirms its importance in both immune system and blood cell development.

ZBTB46 has associations with immunological disorders such as autoimmune diseases and inflammatory conditions. Dysregulation of ZBTB46 expression can contribute to abnormal immune responses potentially leading to chronic inflammation or autoimmunity. In conditions like systemic lupus erythematosus ZBTB46 dysregulation may occur in connection with proteins like STAT3 influencing disease progression and severity. This establishes ZBTB46 as a potential target for therapeutic interventions aiming to modulate immune function in such disorders.
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Specifications

Form

Liquid

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General info

Function

Transcription regulator that mediates differentiation of conventional and non-conventional dendritic cells, and which is involved in tolerance to gut microbiota. Together with RORgammaT (RORC), specifically expressed in type 3 innate lymphoid cells (ILC3s) that are required for tolerance to gut microbiota, to mediate differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms. Functions as a transcription corepressor for PRDM1.

Post-translational modifications

Sumoylated. Desumoylation by DESI1 reverses transcriptional repression activity.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcription regulator that mediates differentiation of conventional and non-conventional dendritic cells, and which is involved in tolerance to gut microbiota. Together with RORgammaT (RORC), specifically expressed in type 3 innate lymphoid cells (ILC3s) that are required for tolerance to gut microbiota, to mediate differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms. Functions as a transcription corepressor for PRDM1.
See full target information ZBTB46
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Product promise

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