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AB196085

Recombinant Human ZBTB9 protein (His tag)

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Recombinant Human ZBTB9 protein (His tag) is a Human Full Length protein, in the 1 to 473 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Zinc finger and BTB domain-containing protein 9, ZBTB9

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q96C00

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"METPTPLPPVPASPTCNPAPRTIQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIEADAFEGLLQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRELETSGGGISARGGNSYHALLSTTSSTGGWCIRSSPFQTPVQSSASTESPASTESPVGGEGSELGEVLQIQVEEEEEEEEDDDDEDQGSATLSQTPQPQRVSGVFPRPHGPHPLPMTATPRKLPEGESAPLELPAPPALPPKIFYIKQEPFEPKEEISGSGTQPGGAKEETKVFSGGDTEGNGELGFLLPSGPGPTSGGGGPSWKPVDLHGNEILSGGGGPGGAGQAVHGPVKLGGTPPADGKRFGCLCGKRFAVKPKRDRHIMLTFSLRPFGCGICNKRFKLKHHLTEHMKTHAGALHACPHCGRRFRVHACFLRHRDLCKGQGWATAHWTYKLEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"51.67 kDa","actualMolecularWeight":null,"aminoAcidEnd":473,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96C00","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB9 also known as Zinc Finger and BTB Domain-Containing Protein 9 is a transcription factor involved in gene expression regulation. It has an approximate mass of 56 kDa. The protein contains a conserved C2H2-type zinc finger domain which allows it to bind specific DNA sequences and modulate transcription. ZBTB9 is mainly expressed in the human brain and various tissues indicating a broad role in physiological processes. This protein's activity is essential for the regulation of genes involved in numerous cellular functions.
Biological function summary

Expertise in transcription regulation reveals ZBTB9 as a significant player. It often functions individually but can associate with other proteins to form complexes that may influence its role in transcription repression or activation. ZBTB9 interacts with different transcriptional co-repressors and co-activators to control the expression of target genes involved in cell cycle regulation apoptosis and differentiation. This precise gene regulation allows the cell to respond to various developmental and external stimuli maintaining cellular homeostasis.

Pathways

Current studies connect ZBTB9 to important transcriptional pathways like the Wnt signaling path and the cell cycle control path. In the Wnt pathway ZBTB9 interacts with proteins such as β-catenin to modulate gene expression important for cell proliferation and differentiation. In the cell cycle path it may interact with key regulators like cyclins and CDKs to influence cell division ensuring proper cell cycle progression and arrest when necessary. These interactions place ZBTB9 as a pivotal mediator in pathways affecting cellular growth and development.

Understanding the connection of ZBTB9 to pathological conditions can provide insights into its clinical significance. ZBTB9 has shown relevance in neurodegenerative diseases particularly Alzheimer's disease due to its expression in the brain and association with neural cell functions. It also appears in studies related to cancer biology with connections to proteins such as p53 indicating a role in tumorigenesis processes like cell cycle dysregulation and apoptosis resistance. These associations suggest that ZBTB9 could be a potential target for therapeutic strategies in diseases where its pathways and interactions are disrupted.
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Specifications

Form

Lyophilized

Additional notes

The purity of ab196085 is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

May be involved in transcriptional regulation.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in transcriptional regulation.
See full target information Zinc finger and BTB domain-containing protein 9
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Complementary Products

Primary Antibodies

AB106628

Anti-ZBTB9 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZBTB9 antibody (AB106628)

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