Recombinant Human ZCCHC12 protein (denatured) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).
SIZN1, ZCCHC12, Zinc finger CCHC domain-containing protein 12, Smad-interacting zinc finger protein 1
Recombinant Human ZCCHC12 protein (denatured) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).
Belongs to the ZCCHC12 family.
ZCCHC12 also known as zinc finger CCHC domain-containing protein 12 is a protein that plays a significant role in transcriptional regulation. This protein has a mass of approximately 64 kDa and is widely expressed in various tissues with significant levels found in the brain. It contains CCHC-type zinc finger domains that facilitate its interaction with nucleic acids contributing to its regulatory functions. The gene encoding ZCCHC12 is located on chromosome 15 and its expression patterns suggest an involvement in neural activity and development.
ZCCHC12 influences gene expression by participating in RNA processing activities. It is not known to be part of a larger complex but acts independently to modulate the stability and translation of specific mRNA transcripts. Research indicates its involvement in maintaining neuronal homeostasis as it directly influences synaptic function and plasticity. The protein's role in regulating neuronal gene expression is important for normal central nervous system function.
The protein interacts with molecular mechanisms such as the JAK-STAT signaling pathway and the mTOR pathway both important for cellular growth and immune response. Within these pathways ZCCHC12 often interacts with proteins like STAT3 and mTOR which play roles in cell proliferation and metabolism. These interactions underline its importance in maintaining cellular architecture and functional dynamics.
ZCCHC12 shows connections to neurological disorders particularly those related to cognitive impairment and neurodegenerative diseases. Altered expression or mutations in the ZCCHC12 gene is associated with conditions such as Alzheimer's disease and specific forms of epilepsy. Through these diseases ZCCHC12 interplays with proteins like tau and amyloid precursor protein (APP) which are key in disease pathogenesis. Understanding ZCCHC12's role offers insights into potential therapeutic targets for these complex diseases.
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15% SDS-PAGE analysis of 3ug ab181905 stained with Coomassie Blue.
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