Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus)
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Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
SIZN1, ZCCHC12, Zinc finger CCHC domain-containing protein 12, Smad-interacting zinc finger protein 1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus) (AB181905)
15% SDS-PAGE analysis of 3ug ab181905 stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ZCCHC12 influences gene expression by participating in RNA processing activities. It is not known to be part of a larger complex but acts independently to modulate the stability and translation of specific mRNA transcripts. Research indicates its involvement in maintaining neuronal homeostasis as it directly influences synaptic function and plasticity. The protein's role in regulating neuronal gene expression is important for normal central nervous system function.
Pathways
The protein interacts with molecular mechanisms such as the JAK-STAT signaling pathway and the mTOR pathway both important for cellular growth and immune response. Within these pathways ZCCHC12 often interacts with proteins like STAT3 and mTOR which play roles in cell proliferation and metabolism. These interactions underline its importance in maintaining cellular architecture and functional dynamics.
Specifications
Form
Liquid
General info
Function
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).
Sequence similarities
Belongs to the ZCCHC12 family.
Target data
Complementary Products
Product promise
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