Recombinant Human ZCCHC3 protein (GST tag N-Terminus)
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Recombinant Human ZCCHC3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 403 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
C20orf99, ZCCHC3, Zinc finger CCHC domain-containing protein 3
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human ZCCHC3 protein (AB164746)
ab164746 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ZCCHC3 plays a role in the immune response. It is linked to the sensing and signaling pathways that are triggered by viral infection. ZCCHC3 does not function independently as it associates with other molecules to form larger protein complexes. It assists in the recognition of viral RNA and helps activate downstream signaling pathways leading to the production of type I interferons and other cytokines that are critical elements of the antiviral response.
Pathways
ZCCHC3 influences important immune signaling mechanisms. It is part of the RIG-I-like receptor (RLR) signaling pathway which detects viral RNAs and activates immune responses. In these pathways ZCCHC3 interacts with proteins such as RIG-I and MDA5. These interactions support antiviral defense mechanisms leading to the induction of interferon production and establishment of an antiviral state in infected and neighboring cells.
Specifications
Form
Liquid
General info
Function
Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed : 30135424, PubMed : 30193849). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed : 30135424, PubMed : 30193849). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed : 30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed : 30135424). Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms : binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed : 30193849).
Target data
Complementary Products
Product promise
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