Recombinant human ZCH11 protein (Tagged)
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Recombinant human ZCH11 protein (Tagged) is a Human Fragment protein, in the 212 to 1313 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE, FuncS.
View Alternative Names
KIAA0191, ZCCHC11, TUT4, Terminal uridylyltransferase 4, TUTase 4, Zinc finger CCHC domain-containing protein 11
- FuncS
Supplier Data
Functional Studies - Recombinant human ZCH11 protein (Tagged) (AB271776)
Functional studies of ab271776.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human ZCH11 protein (Tagged) (AB271776)
SDS-PAGE analysis of ab271776.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ZCH11 plays an important role in regulating gene expression impacting cellular differentiation and development. It acts as an important element in cellular processes and is often part of larger protein complexes that collaborate to control transcription. Through its function as a transcription factor ZCH11 contributes to the maintenance of cellular homeostasis and is essential for normal cellular function.
Pathways
ZCH11 is actively involved in the Wnt signaling and cell cycle regulation pathways. In the Wnt signaling pathway ZCH11 interacts with proteins such as β-catenin influencing gene expression related to cell proliferation and differentiation. In the context of cell cycle regulation ZCH11 interacts with cyclins and cyclin-dependent kinases ensuring proper progression through various phases of the cell cycle.
Specifications
Form
Liquid
General info
Function
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed : 25480299, PubMed : 31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed : 25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed : 19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed : 25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed : 25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed : 16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed : 18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed : 16643855, PubMed : 18172165, PubMed : 19703396, PubMed : 25480299, PubMed : 25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed : 30122351).
Sequence similarities
Belongs to the DNA polymerase type-B-like family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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