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AB202212

Recombinant Human ZFAND5 protein (His tag N-Terminus)

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Recombinant Human ZFAND5 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 213 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ZA20D2, ZNF216, ZFAND5, AN1-type zinc finger protein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216

1 Images
SDS-PAGE - Recombinant Human ZFAND5 protein (AB202212)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ZFAND5 protein (AB202212)

15% SDS-PAGE analysis of ab202212 (3 μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O76080

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADTSLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI","proteinLength":"Full Length","predictedMolecularWeight":"25.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O76080","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZFAND5 also known as ZNF216 is a protein involved mechanically in protein degradation processes. It has a molecular mass of approximately 24 kDa. This protein is known for its expression in various tissues including muscle and liver. ZFAND5 functions as an adaptor that facilitates the recruitment of proteins to proteasomes aiding in the removal of misfolded or damaged proteins within cells.
Biological function summary

ZFAND5 has a significant role in maintaining cellular protein homeostasis. The protein is part of a complex involving the ubiquitin-proteasome system. This complex acts to recognize proteins marked for degradation. By interacting with the proteasome ZFAND5 enhances the degradation process which is essential for cellular health and function. Its activity ensures the smooth turnover of cellular proteins preventing accumulation that can lead to cellular stress.

Pathways

ZFAND5 participates in protein degradation pathways including the ubiquitin-proteasome pathway and the autophagy-lysosome pathway. In the ubiquitin-proteasome pathway ZFAND5 works alongside ubiquitin tagging proteins for destruction. The interplay with other key proteins like ubiquitin ligase highlights its importance in ensuring proteins are correctly degraded and recycled maintaining cellular balance and function.

Aberrant function or expression of ZFAND5 relates to neurodegenerative diseases such as Alzheimer's disease. In Alzheimer's the failing protein degradation can lead to harmful accumulation of proteins like amyloid-beta in which ZFAND5's role becomes critical. Additionally the protein associates with chronic inflammatory disorders where proper protein turnover is disrupted connecting with inflammatory mediators through faulty pathways. Understanding ZFAND5's activity offers insights into tackling these conditions effectively.
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Specifications

Form

Liquid

Additional notes

ab202212 was purified using conventional chromatography.

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General info

Function

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

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Product protocols

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Target data

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
See full target information ZFAND5
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