Recombinant Human ZFP161 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZFPL1 also known as zinc finger protein 161 is a DNA-binding protein characterized by zinc finger motifs that enable it to regulate transcription. It weighs approximately 55 kDa. ZFP161 primarily locates in the nucleus and shows expression across various tissues including the brain liver and kidneys. It functions by binding to specific DNA sequences influencing gene expression patterns necessary for cellular processes.

Biological function summary

ZFP161 plays a role in the regulation of gene expression that affects cellular differentiation and proliferation. It often operates within large protein complexes interacting with other transcription factors and regulatory proteins to modulate gene activity. By influencing the transcriptional landscape ZFP161 helps maintain the balance of gene expression necessary for normal cell function. Reports indicate ZFP161's relevance in the differentiation pathways of neural and hematopoietic cells.

Pathways

ZFP161 engages in key biological pathways such as the Wnt signaling pathway and DNA damage response. In the Wnt pathway it contributes to the regulation of gene targets involved in cell fate decision working alongside proteins like β-catenin. In the DNA damage response its modulation helps maintain genomic stability interacting with proteins such as p53 to repair damaged DNA and prevent mutations.

ZFP161 has connections to neurodegenerative conditions and cancer. In neurodegenerative diseases alterations in ZFP161 expression can disrupt normal neural cell differentiation and function potentially linking to conditions like Alzheimer's disease. Its interactions with proteins like tau suggest a role in neuronal integrity. In cancer aberrant ZFP161 activity might lead to uncontrolled cell proliferation implicated in tumorigenesis especially in relation to p53 mutations and pathways. These associations make ZFP161 a potential target for therapeutic interventions in these disorders.