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AB183253

Recombinant Human Zhangfei protein

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Recombinant Human Zhangfei protein is a Human Full Length protein, in the 1 to 354 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ZF, CREBZF, CREB/ATF bZIP transcription factor, Host cell factor-binding transcription factor Zhangfei, HCF-binding transcription factor Zhangfei

1 Images
SDS-PAGE - Recombinant Human Zhangfei protein (AB183253)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Zhangfei protein (AB183253)

15% SDS PAGE analysis of ab183253 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NS37

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMRHSLTKLLAASGSNSPTRSESPEPAATCSLPSDLTRAAAGEEETAAAGSPGRKQQFGDEGELEAGRGSRGGVAVRAPSPEEMEEEAIASLPGEETEDMDFLSGLELADLLDPRQPDWHLDPGLSSPGPLSSSGGGSDSGGLWRGDDDDEAAAAEMQRFSDLLQRLLNGIGGCSSSSDSGSAEKRRRKSPGGGGGGGSGNDNNQAATKSPRKAAAAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANETGLARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQKQDLLEEDDSAGGVCLHVDKDKVSVEFCSACARKASSSLKM","proteinLength":"Full Length","predictedMolecularWeight":"39.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":354,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NS37","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Zhangfei also known as ZF or ZBTB16 acts as a transcription factor. It belongs to the BTB/POZ family and has a molecular weight of approximately 77 kDa. Researchers have found it expressed in various tissues including the central nervous system and immune cells. Zhangfei interacts mechanistically with other proteins through its BTB domain modulating transcriptional activity.
Biological function summary

This transcription factor regulates the expression of genes important for immune responses and neuronal functions. It forms part of complexes that modulate transcriptional repression often working with corepressors like N-CoR or SMRT. Zhangfei has a role in shaping developmental processes by influencing gene expression in specific lineages providing guidance during cell differentiation.

Pathways

Zhangfei influences gene regulation pathways that encompass the NF-kB and TGF-beta signaling. It interacts with proteins such as IKKs in the NF-kB pathway to modulate inflammation responses. In the TGF-beta pathway Zhangfei plays a role in cellular differentiation processes connecting with proteins like Smad3 to ensure proper signal transduction and output.

Zhangfei's dysregulation links to neurological disorders and certain cancers. It connects with proteins involved in these diseases such as p53 and c-Myc influencing cell cycle control and apoptotic pathways. Evidence suggests altered Zhangfei activity may contribute to neurodegenerative conditions and impacts tumor progression by affecting cellular growth signals.
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Specifications

Form

Liquid

Additional notes

ab183253 is purified using conventional chromatography techniques.

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General info

Function

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

Sequence similarities

Belongs to the bZIP family. ATF subfamily.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
See full target information CREBZF
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