Recombinant Human Zinc finger protein 829

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Zinc finger protein 829 (ZNF829) is a transcription factor belonging to the zinc finger protein family known for its role in DNA binding. ZNF829 has a molecular weight of approximately 68 kDa and is known to bind zinc ions to facilitate its function. This protein is commonly expressed in various tissues with significant presence in the brain. As a transcription factor ZNF829 selectively binds to DNA influencing the transcription of specific genes.

Biological function summary

ZNF829 influences gene expression by regulating transcriptional activities. It may work as part of a transcriptional regulation complex associating with other transcription factors and co-regulators. This protein can affect developmental and differentiation processes by either activating or repressing target gene expression. The regulation ZNF829 offers is necessary for cell-specific responses impacting cellular processes such as proliferation and differentiation.

Pathways

ZNF829 plays roles in essential cellular signaling pathways. One key pathway it engages with is the PI3K/AKT pathway which controls various cellular activities including growth proliferation and survival. ZNF829 also intersects with pathways involving Wnt signaling contributing to developmental processes and maintaining cellular homeostasis. Within these pathways related proteins such as AKT and Glycogen synthase kinase-3 (GSK-3) interact with ZNF829 influencing signaling cascades that regulate these pathways.

ZNF829 and its related functions associate with neurological conditions and cancer. Alterations in the expression or mutation of ZNF829 have correlations with neurodevelopmental disorders which may involve proteins like MECP2 known for their role in neuronal function. In oncology changes in ZNF829 activity or expression can relate to oncogenic processes contributing to the development or progression of tumors. This is particularly relevant in cancers where there's aberration in pathways that ZNF829 is part of interfacing with proteins like AXL which also impact tumor growth and survival.