Recombinant Human ZNDR1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNDR1 also known as Zinc Finger Domain-containing Protein 1 functions as a DNA-binding protein. With an approximate mass of 45 kDa ZNDR1 plays an important role in regulating transcriptional activities by interacting with specific DNA sequences. Researchers have identified the expression of ZNDR1 predominantly in the nucleus of various cell types including those in the liver brain and immune system highlighting its widespread involvement in cellular functions.

Biological function summary

ZNDR1 impacts transcription regulation by acting as a component of a larger protein complex. This complex works to modulate the expression of genes involved in cellular growth differentiation and immune responses. By binding to regulatory regions of DNA ZNDR1 influences RNA polymerase activity and gene transcription. Its role within this complex allows it to integrate signals from cellular pathways acting as an important mediator in cellular function.

Pathways

ZNDR1 has significant roles in the NF-kB and MAPK signaling pathways. In the NF-kB pathway it interacts with proteins like RelA to coordinate immune response and cell survival signals. The MAPK pathway also sees contributions from ZNDR1 where it assists in transmitting signals from extracellular stimuli to the nucleus affecting gene expression related to cell division and stress responses. These pathways underline ZNDR1's importance in managing cellular responses to environmental changes.

ZNDR1 associations include its potential involvement in cancer and autoimmune diseases. Abnormal expression patterns or mutations of ZNDR1 might contribute to oncogenesis by disrupting important transcriptional regulation and its interaction with NF-kB pathway proteins like IKKβ can exacerbate inflammation potentially leading to autoimmune conditions. Understanding ZNDR1's role in these pathological states could offer new insights into therapeutic interventions.