Recombinant Human ZNF10 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF10 also known as KOX1 is a zinc finger protein that functions as a transcriptional repressor. This protein has an approximate mass of 68 kDa. It belongs to the Krüppel-associated box (KRAB) family which is characterized by the presence of a KRAB domain involved in gene silencing. ZNF10 contains multiple C2H2-type zinc finger motifs that facilitate its binding to specific DNA sequences thereby modulating the activity of target genes. This protein shows expression in various tissues including heart brain and placenta indicating its potential involvement in critical physiological functions.

Biological function summary

ZNF10 regulates gene expression by interacting with other proteins to form a complex involved in chromatin remodeling. It acts primarily in the nucleus where it modifies the chromatin structure to repress or activate genes. Studies suggest ZNF10 has a role in developmental processes and may contribute to the regulation of cell differentiation and growth. It can interact with histone deacetylases (HDACs) that remove acetyl groups from histones resulting in chromatin condensation and transcriptional repression indicating a mechanism for controlling gene activity.

Pathways

ZNF10 participates in genetic and epigenetic regulation pathways specifically impacting gene transcription and chromatin organization. It is involved in the gene silencing pathway where it engages with proteins like HDAC1 and KAP1 to exert its repressive effects. This involvement places ZNF10 within the broader context of transcriptional regulation where it plays an important part in maintaining cellular homeostasis and supporting processes such as immune response and neurodevelopment.

ZNF10 has associations with cancer and mental disorders such as schizophrenia. Its dysregulation can lead to aberrant gene expression patterns that promote oncogenesis. Researchers have linked ZNF10 to DNA damage response pathways where improper function can result in cancerous growths. In schizophrenia altered ZNF10 function might influence neurological pathways involving proteins like DISC1 that are important for brain development and function. These links emphasize the importance of ZNF10 in understanding disease mechanisms and developing potential therapeutic targets.