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AB152046

Recombinant Human ZNF100 protein

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Recombinant Human ZNF100 protein is a Human Fragment protein, in the 1 to 109 aa range, expressed in Escherichia coli, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Zinc finger protein 100, ZNF100

Key facts

Purity

>95% SDS-PAGE

ab152046 was determined to be >95% pure by SEC-HPLC and reducing SDS-PAGE.

Endotoxin level

< 0.1 EU/µg

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q8IYN0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Preservative: 0.34% Imidazole Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.01% Zinc chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MDDPRYGMCPLKGASGCPGAERSLLVQSYFEKGPLTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLAGIALTKPDLITCLEQGKEPWNIKRHEMVAKPPVI","proteinLength":"Fragment","predictedMolecularWeight":"12.36 kDa","actualMolecularWeight":null,"aminoAcidEnd":109,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8IYN0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF100 also known as Zinc Finger Protein 100 is a zinc finger transcription factor with an approximate molecular mass of 88 kDa. It functions mechanically by binding to specific DNA sequences using its zinc finger domains regulating the expression of target genes. ZNF100 is expressed in various tissues but shows higher levels in the brain and testis. Its presence in different cellular locations indicates a broad role in transcription control across multiple biological processes.
Biological function summary

Zinc Finger Protein 100 modulates transcription by influencing chromatin structure and gene activity. While it is not part of a well-defined complex it interacts with various other proteins to exert its regulatory effects. This transcription factor plays an important role in cellular differentiation and development contributing to the regulation of genes involved in these processes. ZNF100 has implications in nervous system development given its expression patterns and functional roles.

Pathways

Zinc Finger Protein 100 operates in the transcriptional regulation pathway where it impacts the transcription regulatory network. It participates in pathways affecting cellular proliferation and differentiation. It shows interactions with proteins such as histone deacetylases which are involved in modifying chromatin structure. ZNF100 engages in signaling pathways that interplay with key developmental and cell cycle regulation components coordinating cellular responses during development.

An aberrant function of ZNF100 has links to neurodevelopmental disorders and certain cancers. Its dysregulation may contribute to conditions like autism spectrum disorders aligning with its role in brain development and differentiation. Studies hint at a connection between ZNF100 and proteins like p53 in cancer pathways suggesting a potential role in tumorigenesis. Understanding the function and regulation of ZNF100 can provide insight into these conditions and aid in identifying therapeutic targets.
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General info

Function

May be involved in transcriptional regulation.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in transcriptional regulation.
See full target information ZNF100
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Product promise

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