Recombinant Human ZNF133 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF133 also known as Zinc Finger Protein 133 is a transcription factor featuring multiple zinc finger domains. It has a molecular mass of approximately 85 kDa. This protein binds to specific DNA sequences regulating gene expression. ZNF133 is expressed in various tissues with notable expression in the brain. Its zinc finger domains facilitate the binding to DNA influencing transcriptional activity. The localization and expression patterns hint at its involvement in important cellular processes.

Biological function summary

ZNF133 acts as a regulatory factor influencing chromatin organization and gene expression. It may not typically form part of large protein complexes but functions effectively in modulating gene expression by altering chromatin states. These alterations impact cellular differentiation development and neuronal functions. By affecting DNA accessibility ZNF133 plays an important role in the regulation of gene transcription related to multiple biological processes.

Pathways

The regulatory influence of ZNF133 plays a role in the Wnt signaling pathway as well as neuronal differentiation pathways. In the Wnt signaling pathway ZNF133 potentially modulates the expression of genes critical for cell proliferation and differentiation. Within neuronal differentiation it may interact with proteins like SOX2 to regulate genes essential for neural development. These interactions connect ZNF133 to broader cellular signaling and differentiation networks indicating its importance in maintaining cellular homeostasis.

ZNF133's involvement with neural pathways links it to neurological disorders such as Rett syndrome. In Rett syndrome the abnormal expression of genes regulated by ZNF133 may contribute to the disease phenotype possibly through proteins like MeCP2. Additionally alterations in ZNF133 expression or function might relate to some forms of cancer through disruption of typical gene regulation mechanisms although further research is needed to elucidate these connections fully.