Recombinant Human ZNF184 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF184 also known as Zinc Finger Protein 184 has a role in transcriptional regulation. It functions by binding to specific DNA sequences influencing the expression of target genes. ZNF184 has a mass of approximately 69 kDa. Researchers find its expression in various tissues including the brain and liver. The protein's presence in these regions suggests potential involvement in cell differentiation and development processes.

Biological function summary

In several developmental processes ZNF184 acts as a transcription factor that interacts with the Sp/KLF family of proteins. It plays a part in regulating cell growth and differentiation by modulating the transcription of specific genes. ZNF184 may act as a part of larger protein complexes affecting gene expression patterns important for cellular functions. Its activity could link to chromatin remodeling impacting how genes are accessed by the transcriptional machinery.

Pathways

ZNF184 participation includes its influence in the Wnt signaling pathway and Notch signaling pathway. Through these pathways ZNF184 interacts with proteins like beta-catenin and Notch receptors impacting cell fate determinations. Its involvement in Wnt signaling connects it to gene transcription regulation while interaction with Notch signaling influences cellular communication and development across various tissues.

ZNF184 has associations with neurological conditions such as autism spectrum disorders and schizophrenia. Studies suggest that mutations or misregulation of ZNF184 may affect brain development linking it to these disorders. Additionally ZNF184 interacts with proteins such as DISC1 in the context of schizophrenia highlighting its potential role in neurodevelopmental abnormalities. This connection highlights its importance in maintaining proper neural function and development.